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1. WO2000041508 - COMBINATION THERAPY OF CANCER BY THE ACTIVATION OF CO-STIMULATORY MOLECULES EXPRESSED BY IMMUNE CELLS AND CYTOKINES

Publication Number WO/2000/041508
Publication Date 20.07.2000
International Application No. PCT/US2000/001002
International Filing Date 14.01.2000
Chapter 2 Demand Filed 07.08.2000
IPC
A61K 38/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 38/208
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
208IL-12
A61K 39/39541
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
39541against normal tissues, cells
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/70575
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
C07K 16/2878
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2878against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
Applicants
  • MOUNT SINAI SCHOOL OF MEDICINE OF THE CITY UNIVERSITY OF NEW YORK [US/US]; One Gustave Levy Place New York, NY 10029-6574, US
Inventors
  • CHEN, Shu-Hsia; US
  • WOO, Savio, L., C.; US
Agents
  • CORUZZI, Laura, A. ; Pennie & Edmonds LLP 1155 Avenue of the Americas New York, NY 10036, US
Priority Data
60/115,99215.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATION THERAPY OF CANCER BY THE ACTIVATION OF CO-STIMULATORY MOLECULES EXPRESSED BY IMMUNE CELLS AND CYTOKINES
(FR) POLYTHERAPIE CONTRE LE CANCER S'EFFECTUANT PAR ACTIVATION DE MOLECULES DE CO-STIMULATION EXPRIMEES PAR DES CELLULES IMMUNITAIRES ET DES CYTOKINES
Abstract
(EN)
The present invention relates to methods and compositions for the treatment, prevention or inhibition of diseases and disorders, including cancer, inflammatory diseases or disorders, and infectious diseases, comprising compounds which augment activated immune cells, $i(i.e.), T-cells and natural killer ('NK') cells. In particular, the present invention relates to methods and compositions for the treatment, prevention or inhibition of diseases and disorders, including cancer, inflammatory diseases or disorders, and infectious diseases, comprising the administration of a compound that activates one or more cytokine receptors and a compound that activates one or more co-stimulatory molecules expressed by activated immune cells, $i(i.e.), activated T-cells.
(FR)
L'invention porte sur des méthodes et des compositions destinées au traitement, à la prévention ou à l'inhibition de maladies ou de troubles (notamment le cancer, les maladies ou troubles inflammatoires, ou les maladies infectieuses), et contenant des composés pouvant augmenter des cellules immunitaires activées, telles que les lymphocytes T ou les cellules NK. L'invention porte en particulier sur des méthodes et des compositions destinées au traitement, à la prévention ou à l'inhibition de maladies ou de troubles (notamment le cancer, les maladies ou troubles inflammatoires, ou les maladies infectieuses), qui consistent à administrer un composé capable d'activer un ou plusieurs récepteurs de la cytokine, ou un composé capable d'activer une ou plusieurs molécules co-stimulantes exprimées par des cellules immunitaires activées, telles que des lymphocytes T activés.
Also published as
Latest bibliographic data on file with the International Bureau