Processing

Please wait...

Settings

Settings

1. WO2000040950 - REACTION MONITORING

Publication Number WO/2000/040950
Publication Date 13.07.2000
International Application No. PCT/SE1999/002473
International Filing Date 22.12.1999
Chapter 2 Demand Filed 03.07.2000
IPC
G01N 21/65 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
65Raman scattering
CPC
G01N 2021/651
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
65Raman scattering
651Cuvettes therefore
G01N 2021/656
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
65Raman scattering
653Coherent methods [CARS]
656Raman microprobe
G01N 21/65
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
65Raman scattering
Applicants
  • ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje, SE (AllExceptUS)
  • JOSEFSON, Mats [SE/SE]; SE (UsOnly)
  • LANGKILDE, Frans [DK/DK]; SE (UsOnly)
  • SVENSSON, Olof [SE/SE]; SE (UsOnly)
Inventors
  • JOSEFSON, Mats; SE
  • LANGKILDE, Frans; SE
  • SVENSSON, Olof; SE
Agents
  • ASTRAZENECA AB; Intellectual Property, Patents S-151 85 Södertälje, SE
Priority Data
9900030-905.01.1999SE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REACTION MONITORING
(FR) SUIVI DE REACTIONS
Abstract
(EN)
This invention relates to a method for monitoring a chemical reaction of pharmaceutical relevance, comprising the steps of: consecutively obtaining Raman spectrum samples of a solution of chemical constituents contained within a reaction vessel, by irradiating, with substantially monochromatic radiation, said solution and detecting the scattered radiation; processing said Raman spectrum samples by means of a multivariate data analysis (MVDA) for consecutively generating at least a first main component related to a latent variable indicative of the progress of the reaction wherein the multivariate data analysis is independent from calibration using reference measurements of objects having a known composition; and determining the extent of the chemical reaction on basis of said at least a first main component and optionally on basis of additionally one or more main components generated from one or more previously run reactions of the same kind.
(FR)
L'invention porte sur un procédé de suivi d'une réaction chimique à caractère pharmaceutique comportant les étapes suivantes: (1) obtention consécutive d'échantillons des spectres de Raman d'une solution de constituant chimiques présente dans le bac de réaction en l'irradiant par un rayonnement quasi monochromatique puis en détectant le rayonnement diffusé; (2) traitement desdits échantillons par analyse MVDA (analyse de données à variables multiples), puis élaboration d'au moins une première composante liée à une variable latente indicatrice du progrès de la réaction, l'analyse MVDA étant indépendante de l'étalonnage si on utilise des mesures relatives à des objets de composition connue; et (3) détermination de l'étendue de la réaction chimique sur la base d'au moins ce premier composant principal et facultativement sur la base d'un ou plusieurs composants principaux obtenus à partir de réactions antérieures de même nature.
Also published as
ININ/PCT/2001/00749/MUM
NZ512434
US09530251
Latest bibliographic data on file with the International Bureau