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1. WO2000040723 - METHODS AND PRODUCTS FOR DELIVERING NUCLEIC ACIDS

Publication Number WO/2000/040723
Publication Date 13.07.2000
International Application No. PCT/US2000/000212
International Filing Date 04.01.2000
Chapter 2 Demand Filed 21.07.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12N 15/87 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C12N 15/87
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Applicants
  • UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE [US/US]; Burlington, VT 05405, US
Inventors
  • HEINTZ, Nicholas, H.; US
  • HOUCHENS, Christopher, R.; US
Agents
  • LOCKHART, Helen, C.; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210, US
Priority Data
60/114,74304.01.1999US
60/114,74504.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND PRODUCTS FOR DELIVERING NUCLEIC ACIDS
(FR) METHODES ET PRODUITS SERVANT A L'ADMINISTRATION D'ACIDES NUCLEIQUES
Abstract
(EN)
The invention relates to products and methods for delivering nucleic acids of various sizes and preferably greater than 50 kilobases into cells. The nucleic acids are delivered as part of a nucleic acid delivery complex which is composed of at least a nucleic acid binding and condensation domain. The invention also relates to nucleic acids and encoded polypeptides from the human zinc finger protein RIP60. The invention provides, $i(inter alia), isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, fragments of the foregoing including functional fragments and variants. Kits containing the foregoing molecules additionally are provided.
(FR)
L'invention concerne des produits et des méthodes servant à administrer des acides nucléiques de tailles diverses et de préférence supérieurs à 50 kilobases dans des cellules. Lesdits acides nucléiques sont administrés en tant que partie d'un complexe d'apport d'acides nucléiques qui est composé d'au moins un domaine de liaison et de condensation d'acides nucléiques. Cette invention concerne également des acides nucléiques et des polypeptides codés provenant de la protéine humaine à doigts de zinc RIP60. Elle a trait, en outre, à des molécules d'acides nucléiques isolées, à des vecteurs d'expression contenant ces molécules et à des cellules hôtes transfectées par ces molécules. Ladite invention concerne aussi des protéines et des peptides isolés, des fragments desdits peptides et protéines, dont des fragments et variants fonctionnels, ainsi que des kits contenant les molécules susmentionnées.
Also published as
Latest bibliographic data on file with the International Bureau