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1. WO2000040718 - MUTANTS OF GNRPs AND VECTORS SUITABLE FOR THEIR EXPRESSION

Publication Number WO/2000/040718
Publication Date 13.07.2000
International Application No. PCT/EP2000/000012
International Filing Date 04.01.2000
Chapter 2 Demand Filed 31.07.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/4702
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA [IT/IT]; Dipartimento di Biotecnologie e Bioscienze Piazza dell'Ateneo Nuovo, 1 I-20126 Milan, IT (AllExceptUS)
  • ALBERGHINA, Lilia [IT/IT]; IT (UsOnly)
Inventors
  • ALBERGHINA, Lilia; IT
Agents
  • GERVASI, Gemma; Notarbartolo & Gervasi S.p.A. Corso di Porta Vittoria, 9 I-20122 Milan, IT
Priority Data
MI99A00000104.01.1999IT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MUTANTS OF GNRPs AND VECTORS SUITABLE FOR THEIR EXPRESSION
(FR) MUTANTS DE PROTEINES GNRP ET VECTEURS APPROPRIES A L'EXPRESSION DE CEUX-CI
Abstract
(EN)
The present invention relates to an amino acid sequence of a Guanine Nucleotide Releasing Protein (GNRP) spanning a portion of the catalytic domain in which threonine (T) corresponding to position 1184 of the protein of the GNRP class named CDC25Mm is mutated to an acidic amino acid, the gene sequence encoding said amino acid sequence, and their application in the pharmaceutical field, in particular in the treatment of tumors, cardiovascular diseases, arterial restenosis and inflammatory states, or in the diagnostic field.
(FR)
L'invention concerne une séquence d'acides aminés d'une protéine de libération d'un nucléotide contenant guanine (GNRP) recouvrant une portion du domaine catalytique dans lequel la thréonine (T) correspondant à la position 1184 de la protéine de la classe GNRP appelée CDC25Mm est mutée en acide aminé acide; elle concerne également la séquence génique codant ladite séquence d'acides aminés, et l'application de ces séquences dans le domaine pharmaceutique, notamment dans le traitement de tumeurs, de maladies cardio-vasculaires, de resténose artérielle et d'états inflammatoires, ou dans le domaine diagnostique.
Also published as
Latest bibliographic data on file with the International Bureau