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1. WO2000040714 - THERAPEUTIC PHOSPHODIESTERASE INHIBITORS

Publication Number WO/2000/040714
Publication Date 13.07.2000
International Application No. PCT/US1999/029976
International Filing Date 15.12.1999
Chapter 2 Demand Filed 19.07.2000
IPC
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 11/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
16Central respiratory analeptics
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
Applicants
  • OLIGOS ETC. INC. [US/US]; 9775 S.W. Commerce Circle, Building C6 Wilsonville, OR 97070, US (AllExceptUS)
  • DALE, Roderic, M., K. [US/US]; US (UsOnly)
  • ARROW, Amy [US/US]; US (UsOnly)
  • THOMPSON, Terry [US/US]; US (UsOnly)
Inventors
  • DALE, Roderic, M., K.; US
  • ARROW, Amy; US
  • THOMPSON, Terry; US
Agents
  • DEVORE, Dianna, L.; Bozicevic, Field & Francis LLP 200 Middlefield Road, Suite 200 Menlo Park, CA 94025, US
Priority Data
09/223,58630.12.1998US
09/364,62629.07.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC PHOSPHODIESTERASE INHIBITORS
(FR) INHIBITEURS DE LA PHOSPHODIESTERASE UTILISES A DES FINS THERAPEUTIQUES
Abstract
(EN)
This patent describes the invention of a series of novel therapeutic oligonucleotide polymers targeted at inhibiting expression of genes coding for Phosphodiesterase 4. They are useful as analytical tools in the study of individual PDE isoforms and in the therapeutic treatment of depression, thrombosis, cystic fibrosis, gastric lesions, pulmonary hypertension, glaucoma, multiple sclerosis, atopic dermatitis, asthma and other allergic disorders as well as other illnesses in which an increase of cyclic AMP or a decrease in phosphodiesterase levels is useful.
(FR)
L'invention concerne une série de nouveaux polymères oligonucléotidiques thérapeutiques destinés à inhiber l'expression de gènes codant pour la phosphodiestérase 4. Ces polymères oligonucléotidiques thérapeutiques peuvent être utilisés comme outils d'analyse pour l'étude d'isoformes PDE individuelles et pour le traitement de la dépression, de la thrombose, de la mucoviscidose, de lésions gastriques, de l'hypertension pulmonaire, du glaucome, de la sclérose en plaques, de la dermatite atopique, de l'asthme et autres troubles allergiques, ainsi que d'autres maladies dans lesquelles une augmentation de l'AMP cyclique ou une diminution des niveaux de la phosphodiestérase est utile.
Latest bibliographic data on file with the International Bureau