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1. WO2000040613 - INSULIN-LIKE GROWTH FACTOR (IGF) I MUTANT VARIANTS

Publication Number WO/2000/040613
Publication Date 13.07.2000
International Application No. PCT/US2000/000199
International Filing Date 05.01.2000
Chapter 2 Demand Filed 07.02.2001
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/65 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
65Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
C07K 14/65
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
65Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
Applicants
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, CA 94080-4990, US
Inventors
  • DUBAQUIE, Yves; US
  • FIELDER, Paul, J.; US
  • LOWMAN, Henry, B.; US
  • MORTENSEN, Deborah, L.; US
Agents
  • HASAK, Janet, E. ; Genentech, Inc. 1 DNA Way South San Francisco, CA 94080-4990, US
  • BASSETT, Richard; Eric Potter & Clarkson Park View House 58 the Ropewalk Nottingham NG1 5DD, GB
Priority Data
60/115,01006.01.1999US
60/170,26109.12.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INSULIN-LIKE GROWTH FACTOR (IGF) I MUTANT VARIANTS
(FR) VARIANTS MUTANTS DU FACTEUR DE CROISSANCE INSULINOMIMETIQUE (IGF) DE TYPE I
Abstract
(EN)
IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder characterized by dysregulation of the GH/IGF axis in a mammal, such as a renal disorder.
(FR)
L'invention concerne des variants de IGF-I qui possèdent un reste d'acide aminé d'alanine, glycine, ou sérine à l'emplacement 16, 25, 49 ou aux emplacements 3 et 49 de la séquence native de l'IGF-I. Lesdits variants sont utilisés pour traiter un trouble, tel qu'un trouble rénal, caractérisé par une dérégulation de l'axe hormone de croissance/IGF, chez un mammifère.
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