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1. WO2000040579 - NEW 1,4-DISUBSTITUTED CYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION

Publication Number WO/2000/040579
Publication Date 13.07.2000
International Application No. PCT/US2000/000348
International Filing Date 06.01.2000
Chapter 2 Demand Filed 20.07.2000
IPC
C07D 409/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
CPC
C07D 409/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
Applicants
  • AMERICAN HOME PRODUCTS CORPORATION [US/US]; Five Giralda Farms Madison, NJ 07940-0874, US
Inventors
  • MEWSHAW, Richard, Eric; US
  • BAUDY, Reinhardt, Bernhard; US
Agents
  • NAGY, Michael, R.; American Home Products Corporation Patent Law Dept. - 2B One Campus Drive Parsippany, NJ 07054 , US
  • WLEMAN, David Francis; CONNELLY, Michael John; WALTERS, Philip Bernard William; MANNION, Sally Kim; and TALBOTT, Dawn Jacqueline; C/0 Wyeth Laboratories Huntercombe Lane South Taplow Maidenhead Berks SL6 OPH United Kingdom, GB
Priority Data
09/226,55207.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEW 1,4-DISUBSTITUTED CYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION
(FR) ANTIDEPRESSEURS A BASE DE DERIVES DE CYCLOHEXANE 1,4-DISUBSTITUES POUR LE TRAITEMENT DES DEPRESSIONS
Abstract
(EN)
Compounds useful for the treatment of disorders of the serotonin-affected neurological systems are provided which have formula (I) wherein: X is carbon or nitrogen; the dotted line represents an optional bond which is absent when X = N; R1 and R2 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, or MeSO2; R3 is hydrogen, halogen, or alkyl; R4 is hydrogen, alkyl, alkylaryl, or aryl; and R5 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; or a pharmaceutically acceptable salt thereof.
(FR)
L'invention concerne des composés convenant au traitement de troubles du système neurologique liés à la sérotonine, représentés par la formule générale (I) ou l'un de leurs sels pharmaceutiquement admis: Dans cette formule, X représente un carbone ou un azote, le pointillé représente une liaison facultative absente lorsque X=N; R1 et R2 sont chacun, indépendamment, hydrogène, halogène, CF3, alkyle, alcoxyle, ou MeSO2; R3 est hydrogène, halogène, ou alkyle, R4 est hydrogène, alkyle, alkylaryle, ou aryle, et R5 est hydrogène, halogène, CF3, CN, carbamide, ou alcoxyle.
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