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1. WO2000040573 - METHOD FOR HIGH YIELD EXTRACTION OF PACLITAXEL FROM PACLITAXEL-CONTAINING MATERIAL

Publication Number WO/2000/040573
Publication Date 13.07.2000
International Application No. PCT/CA1999/001238
International Filing Date 30.12.1999
Chapter 2 Demand Filed 31.07.2000
IPC
C07D 305/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
14condensed with carbocyclic rings or ring systems
CPC
C07D 305/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atoms as the only ring hetero atoms
14condensed with carbocyclic rings or ring systems
Applicants
  • PHYTOGEN LIFE SCIENCES, INCORPORATED [CA/CA]; 1527 Cliveden Avenue Delta, British Columbia V3M 6P7, CA (AllExceptUS)
  • FOO, Samuel, Siang, Kiang [CA/CA]; CA (UsOnly)
  • BAI, Yili [CA/CA]; CA (UsOnly)
  • EHLERT, Martin [CA/CA]; CA (UsOnly)
Inventors
  • FOO, Samuel, Siang, Kiang; CA
  • BAI, Yili; CA
  • EHLERT, Martin; CA
Agents
  • NASSIF, Omar, A. ; Gowling Lafleur Henderson LLP Suite 4900 Commerce Court West Toronto, Ontario M5L 1J3, CA
  • GOWSHALL Jonathan V.; Forrester & Boehmert Franz-Joseph-Str. 38 D- 80801 München, DE
Priority Data
09/223,69430.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR HIGH YIELD EXTRACTION OF PACLITAXEL FROM PACLITAXEL-CONTAINING MATERIAL
(FR) METHODE D'EXTRACTION A HAUT RENDEMENT DE PACLITAXEL A PARTIR DE MATIERE CONTENANT DU PACLITAXEL
Abstract
(EN)
A method of isolating paclitaxel from paclitaxel-containing material that includes the steps of obtaining an acetone mixture of the paclitaxel-containing material, then mixing the acetone mixture with an aqueous solvent to form an aqueous supernatant and a precipitate, wherein the precipitate contains at least 3-times higher paclitaxel content than the paclitaxel extract. The acetone/water precipitation step provides a high yield of highly pure paclitaxel that is suitable for industrial scale isolation using conventional normal-phase silica chromatography steps, and the preparation of pharmaceutical compositions containing paclitaxel.
(FR)
Une méthode d'isolement de paclitaxel à partir de matière contenant du paclitaxel comprend les étapes consistant à obtenir un mélange d'acétone et de matière contenant du paclitaxel, à mélanger ensuite le mélange à l'acétone avec un solvant aqueux pour former un surnageant aqueux et un précipité, le précipité contenant une teneur en paclitaxel au moins trois fois supérieure à l'extrait de paclitaxel. L'étape de précipitation d'acétone/eau permet d'obtenir un rendement élevé de paclitaxel très pur adapté à un isolement à l'échelle industrielle au moyen d'étapes de chromatographie classique sur silice en phase normale, et la préparation de compositions pharmaceutiques contenant du paclitaxel.
Also published as
ININ/PCT/2001/00751/MUM
ININ/PCT/2001/751/MUM
NO20013276
Latest bibliographic data on file with the International Bureau