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1. WO2000040569 - 2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY

Publication Number WO/2000/040569
Publication Date 13.07.2000
International Application No. PCT/GB2000/000031
International Filing Date 06.01.2000
Chapter 2 Demand Filed 19.07.2000
IPC
C07C 271/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
26with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
28to a carbon atom of a non-condensed six-membered aromatic ring
C07C 271/58 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
40having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
58with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
C07D 265/26 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
041,3-Oxazines; Hydrogenated 1,3-oxazines
12condensed with carbocyclic rings or ring systems
14condensed with one six-membered ring
24with hetero atoms directly attached in positions 2 and 4
26Two oxygen atoms, e.g. isatoic anhydride
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • ALIZYME THERAPEUTICS LIMITED [GB/GB]; Granta Park Great Abington Cambridge CB1 6GS, GB (AllExceptUS)
  • HODSON, Harold, Francis [GB/GB]; GB (UsOnly)
  • DOWNHAM, Robert [GB/GB]; GB (UsOnly)
  • MITCHELL, Timothy, John [GB/GB]; GB (UsOnly)
  • CARR, Beverley, Jane [GB/GB]; GB (UsOnly)
  • DUNK, Christopher, Robert [GB/GB]; GB (UsOnly)
  • PALMER, Richard, Michael, John [GB/GB]; GB (UsOnly)
Inventors
  • HODSON, Harold, Francis; GB
  • DOWNHAM, Robert; GB
  • MITCHELL, Timothy, John; GB
  • CARR, Beverley, Jane; GB
  • DUNK, Christopher, Robert; GB
  • PALMER, Richard, Michael, John; GB
Agents
  • FLORENCE, Julia, Anne; Kilburn & Strode 20 Red Lion Street London WC1R 4PJ, GB
Priority Data
9900416.008.01.1999GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY
(FR) 2-OXY-4H-3,1-BENZOXAZINE-4-ONES DESTINEES AU TRAITEMENT DE L'OBESITE
Abstract
(EN)
The use of a compound comprising formula (I) or a salt, ester, amide or prodrug therof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality, e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I) A is a 6-membered aromatic or heteroaromatic ring; and R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups.
(FR)
L'invention concerne l'utilisation d'un composé de formule (I) ou d'un sel, d'un ester, d'un amide ou d'un promédicament dudit composé, pour inhiber une enzyme dont le mode d'action préféré est de catalyser l'hydrolyse d'une fonctionnalité ester, par exemple pour la régulation et l'inhibition des enzymes indésirables dans les produits et les processus. Ces composés sont également utiles en médecine, par exemple pour le traitement de l'obésité et des pathologies voisines. L'invention concerne également des composés de formule (I), des procédés permettant de les préparer et des compositions pharmaceutiques les contenant. Dans la formule (I), A est un noyau aromatique ou hétéro-aromatique à 6 éléments; et R1 est alkyle ramifié ou non ramifié (éventuellement interrompu par un ou plusieurs atomes d'oxygène), alcényle, alcinyle, cycloalkyle, cycloalcényle, aryle, arylalkyle, arylalkyle réduit, arylalcényle, hétéroaryle, hétéro-arylalkyle, hétéro-arylalcényle, aryle réduit, hétéro-aryle réduit, hétéro-arylalkyle réduit, ou un dérivé substitué de l'un des groupes ci-dessus.
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