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1. WO2000040564 - N-CARBOXYMETHYL SUBSTITUTED BENZOLACTAMS AS INHIBITORS OF MATRIX METALLOPROTEINASE

Publication Number WO/2000/040564
Publication Date 13.07.2000
International Application No. PCT/US1999/028339
International Filing Date 30.11.1999
Chapter 2 Demand Filed 19.06.2000
IPC
A61K 31/55 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07D 223/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14condensed with carbocyclic rings or ring systems
16Benzazepines; Hydrogenated benzazepines
C07D 403/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07K 5/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
C07K 5/078 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
078the first amino acid being heterocyclic, e.g. Pro, His, Trp
CPC
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
C07D 223/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14condensed with carbocyclic rings or ring systems
16Benzazepines; Hydrogenated benzazepines
C07D 403/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07K 5/021
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
021containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
Applicants
  • AVENTIS PHARMACEUTICALS INC. [US/US]; Route 202-206 P.O. Box 6800 Bridgewater, NJ 08807-0800, US
Inventors
  • WARSHAWSKY, Alan; US
  • JANUSZ, Michael, J.; US
  • FLYNN, Gary, A.; US
Agents
  • VOELK, Eric, K.; Aventis Pharmaceuticals Inc. Route 202-206 P.O. Box 6800 Bridgewater, NJ 08807-0800, US
Priority Data
09/224,54931.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) N-CARBOXYMETHYL SUBSTITUTED BENZOLACTAMS AS INHIBITORS OF MATRIX METALLOPROTEINASE
(FR) BENZOLACTAMES A SUBSTITUTION N-CARBOXYMETHYLE INHIBITEURS DE LA METALLOPROTEINASE MATRICIELLE
Abstract
(EN)
The present invention provides a method of inhibiting matrix metallo-proteinases (MMPs) in a patient in need thereof comprising administering to the patient an effective matrix metalloproteinase inhibiting amount of the N-carboxymethyl substituted benzolactams of formula (1) wherein A is -OH or -NRR'. Such inhibitors are useful in treating neoplasms, atherosclorosis, and chronic inflammatory diseases. The present invention also provides novel N-carboxymethyl substituted benzolactams of formula (1a) wherein A is -NRR'.
(FR)
L'invention porte sur un procédé d'inhibition chez un patient le nécessitant des métallo-protéinases (MMPs) consistant à lui administrer une dose inhibitrice efficace de benzolactames à substitution N-carboxyméthyle de formule (1) dans laquelle A est -OH ou -NRR'. Ces inhibiteurs s'utilisent pour traiter les néoplasmes, l'athérosclérose, et les troubles inflammatoires chroniques. L'invention porte également sur de nouveaux benzolactames à substitution N-carboxyméthyle de formule (1a) dans laquelle A est -NRR'.
Also published as
Latest bibliographic data on file with the International Bureau