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1. WO2000040562 - 2-OXOQUINOLINE COMPOUNDS AND MEDICINAL USES THEREOF

Publication Number WO/2000/040562
Publication Date 13.07.2000
International Application No. PCT/JP1999/007398
International Filing Date 28.12.1999
Chapter 2 Demand Filed 06.07.2000
IPC
C07D 215/227 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
22attached in position 2 or 4
227only one oxygen atom which is attached in position 2
C07D 215/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
54attached in position 3
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 215/227
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
22attached in position 2 or 4
227only one oxygen atom which is attached in position 2
C07D 215/54
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
54attached in position 3
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • JAPAN TOBACCO INC. [JP/JP]; 2-1, Toranomon 2-chome Minato-ku, Tokyo 105-8422, JP (AllExceptUS)
  • INABA, Takashi [JP/JP]; JP (UsOnly)
  • KAYA, Tetsudo [JP/JP]; JP (UsOnly)
  • IWAMURA, Hiroyuki [JP/JP]; JP (UsOnly)
Inventors
  • INABA, Takashi; JP
  • KAYA, Tetsudo; JP
  • IWAMURA, Hiroyuki; JP
Agents
  • SHIMIZU, Hatsushi ; Kantetsu Tsukuba Building 6F 1-1-1, Oroshi-machi Tsuchiura-shi, Ibaraki 300-0847, JP
Priority Data
11/349808.01.1999JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) 2-OXOQUINOLINE COMPOUNDS AND MEDICINAL USES THEREOF
(FR) COMPOSES DE 2-OXOQUINOLINE ET LEURS UTILISATIONS MEDICINALES
Abstract
(EN)
2-Oxoquinoline compounds represented by general formula [I] or medicinally acceptable salts thereof; and medicinal uses of both (wherein each symbol is as defined in the description). The compounds [I] and the salts act selectively on cannabinoid receptors, particularly peripheral ones, little have adverse effects on the central nervous system, and exhibit excellent immunosuppressive, anti-inflammatory and antiallergic activities, thus being useful as regulators against cannabinoid receptors (particularly peripheral cannabinoid receptors), and immunosuppressive, anti-inflammatory and antiallergic agents.
(FR)
Composés de 2-oxoquinoline représentés par la formule générale (I) ou leurs sels acceptables en médecine et utilisations médicinales de ceux-ci (formule dans laquelle chaque symbole est tel que défini dans la description). Les composés (I) ainsi que les sels agissent sélectivement sur les récepteurs cannabinoïdes, notamment les récepteurs périphériques, ils présentent peu d'effets secondaires indésirables sur le système nerveux central et ils présentent d'excellentes activités immunodépressives, anti-inflammatoires et anti-allergiques, et ils sont par conséquent utiles en tant que régulateurs contre les récepteurs cannabinoïdes (notamment les récepteurs cannabinoïdes périphériques), et agents immunodépresseurs, anti-inflammatoires et anti-allergiques.
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