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1. WO2000040553 - 3-SUBSTITUTED PYRROLIDINES USEFUL AS INHIBITORS OF MATRIX METALLO-PROTEINASES

Publication Number WO/2000/040553
Publication Date 13.07.2000
International Application No. PCT/US1999/028234
International Filing Date 30.11.1999
Chapter 2 Demand Filed 19.06.2000
IPC
C07D 207/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
CPC
C07D 207/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants
  • AVENTIS PHARMACEUTICALS INC. [US/US]; Route 202-206 P.O. Box 6800 Bridgewater, NJ 08807-0800, US
Inventors
  • FLYNN, Gary, A.; US
Agents
  • VOELK, Eric, K.; Aventis Pharmaceuticals Inc. Route 202-206 P.O. Box 6800 Bridgewater, NJ 08807-0800, US
Priority Data
09/224,45631.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 3-SUBSTITUTED PYRROLIDINES USEFUL AS INHIBITORS OF MATRIX METALLO-PROTEINASES
(FR) PYRROLIDINES 3-SUBSTITUTEES, INHIBITRICES DES METALLO-PROTEINASES MATRICIELLES
Abstract
(EN)
The present invention provides novel 3-substituted pyrrolidines of formula (1) useful as inhibitors of matrix metallo-proteinases (MMPs). Pharmaceutical compositions containing said compounds as well as methods of treating disease states responding to inhibition of matrix metallo-proteinase are also claimed herein.
(FR)
L'invention porte sur de nouvelles pyrrolidines 3-substitutées de formule (1) utilisables comme inhibiteurs des métallo-protéinases matricielles (MMPs), sur des compositions pharmaceutiques les contenant et sur des procédés de traitement conformes à la description de différents états morbides par inhibition des métallo-protéinases matricielles.
Also published as
Latest bibliographic data on file with the International Bureau