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1. WO2000040547 - $g(a)-SUBSTITUTION OF UNPROTECTED $g(b)-AMINO ESTER COMPOUNDS

Publication Number WO/2000/040547
Publication Date 13.07.2000
International Application No. PCT/US1999/030366
International Filing Date 17.12.1999
Chapter 2 Demand Filed 13.07.2000
IPC
C07C 227/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
227Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
30Preparation of optical isomers
32by stereospecific synthesis
C07C 229/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
30the carbon skeleton being acyclic and unsaturated
C07C 253/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
C07C 255/57 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
57containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
CPC
C07B 2200/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
07Optical isomers
C07C 227/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
227Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
30Preparation of optical isomers
32by stereospecific synthesis
C07C 253/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
Applicants
  • AVENTIS PHARMACEUTICALS PRODUCTS INC. [US/US]; Route 202-206 P.O. Box 6800 Mail Code : EMC-G1 Bridgewater, NJ 088070-0800, US (AllExceptUS)
  • CHANDRAMOULI, Sithamalli, V. [IN/US]; US (UsOnly)
  • O'BRIEN, Michael, K. [US/US]; US (UsOnly)
  • POWNER, Tory, H. [US/US]; US (UsOnly)
Inventors
  • CHANDRAMOULI, Sithamalli, V.; US
  • O'BRIEN, Michael, K.; US
  • POWNER, Tory, H.; US
Agents
  • OEHLER, Ross, J. ; Aventis Pharma Products Inc. Route 202-206 P.O. Box 6800 Mail Code : EMC-G1 Bridgewater, NJ 088070-0800, US
Priority Data
60/114,59831.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) $g(a)-SUBSTITUTION OF UNPROTECTED $g(b)-AMINO ESTER COMPOUNDS
(FR) $g(a)-SUBSTITUTION DE COMPOSES DE $g(b)-AMINO ESTERS NON PROTEGES
Abstract
(EN)
Methods for stereoselective substitution in which a (mono or un)-$g(a)-substituted unprotected $g(b)-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hybride, lithium amide, lithium dialkyl amides and alkali hexamethyldisilylamines.
(FR)
L'invention concerne des procédés de substitution stéréosélective dans lesquels on met à réagir un composé de $g(b)-amino ester non protégé (mono ou non)-$g(a) substitué, ou un sel de celui-ci, avec un électrophile aliphatique en présence d'une base sélectionnée dans le groupe constitué par des composés de lithium alkylés, un hydrure de lithium, un amide de lithium, des amides dialkylés de lithium et des hexaméthyldisilylamines alcalines.
Also published as
ININ/PCT/2001/914/CHE
US09491548
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