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1. WO2000040537 - PROCESSES FOR PRODUCING ACRYLIC ACID DERIVATIVE

Publication Number WO/2000/040537
Publication Date 13.07.2000
International Application No. PCT/JP1999/007397
International Filing Date 28.12.1999
Chapter 2 Demand Filed 15.06.2000
IPC
C07B 41/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
41Formation or introduction of functional groups containing oxygen
06of carbonyl groups
C07C 67/343 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
30by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
333by isomerisation; by change of size of the carbon skeleton
343by increase in the number of carbon atoms
C07D 239/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
52Two oxygen atoms
C07D 311/76 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
76Benzo pyrans
CPC
C07B 41/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
41Formation or introduction of functional groups containing oxygen
06of carbonyl groups
C07C 67/343
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
30by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
333by isomerisation; by change of size of the carbon skeleton
343by increase in the number of carbon atoms
C07D 239/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
52Two oxygen atoms
C07D 311/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
76Benzo[c]pyrans
Applicants
  • NIPPON SODA CO., LTD. [JP/JP]; 2-1, Ohtemachi 2-chome Chiyoda-ku, Tokyo 100-8165, JP (AllExceptUS)
  • MIYAZAWA, Yasuyuki [JP/JP]; JP (UsOnly)
  • SAGAE, Takahiro [JP/JP]; JP (UsOnly)
  • ISHII, Hiroshi [JP/JP]; JP (UsOnly)
  • YAZAKI, Hiroyuki [JP/JP]; JP (UsOnly)
  • FUNABORA, Makoto [JP/JP]; JP (UsOnly)
  • TAKASE, Mitsuru [JP/JP]; JP (UsOnly)
  • IIYOSHI, Yoshiyuki [JP/JP]; JP (UsOnly)
  • YAMAZAKI, Satoru [JP/JP]; JP (UsOnly)
  • KAWAHARA, Noriaki [JP/JP]; JP (UsOnly)
Inventors
  • MIYAZAWA, Yasuyuki; JP
  • SAGAE, Takahiro; JP
  • ISHII, Hiroshi; JP
  • YAZAKI, Hiroyuki; JP
  • FUNABORA, Makoto; JP
  • TAKASE, Mitsuru; JP
  • IIYOSHI, Yoshiyuki; JP
  • YAMAZAKI, Satoru; JP
  • KAWAHARA, Noriaki; JP
Agents
  • TOKAI, Yusaku ; Nippon Soda Co., Ltd. 2-1, Ohtemachi 2-chome Chiyoda-ku, Tokyo 100-8165, JP
Priority Data
10/37735329.12.1998JP
11/1375922.01.1999JP
11/1431922.01.1999JP
11/29825720.10.1999JP
11/34830208.12.1999JP
11/34856408.12.1999JP
11/34875208.12.1999JP
11/6665612.03.1999JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PROCESSES FOR PRODUCING ACRYLIC ACID DERIVATIVE
(FR) PROCEDES DE PRODUCTION D'UN DERIVE D'ACIDE ACRYLIQUE
Abstract
(EN)
Processes for producing a compound (1) represented by formula (1), which includes an acrylic acid derivative and is useful as an agricultural chemical or medicine. One of the processes comprises the step of formylating a compound (3) (step (1)) and the step of converting the OH of the resultant compound (2) into OR' (step (2)). The step (1) comprises reacting a formic or orthoformic ester in the presence of a Lewis acid and a base. The step (2) comprises [1] reacting the compound (2) with R' OH or with R' OH and CH(OR')3 under acidic conditions or [2] using a phase-transfer catalyst in a two-phase system and regulating the base and the concentration thereof to stereoselectively synthesize the target compound. In another process, the compound (1) is efficiently produced without isolating the compound (2). In still another process, the compound (1) is directly produced without via the compound (2).
(FR)
L'invention concerne des procédés de production d'un composé (I) représenté par la formule (1) composé (3), composé (2), composé (1), lequel contient un dérivé d'acide acrylique et est utile en tant qu'agent chimique agricole ou médicament. Un des procédés comprend l'étape consistant à formyler un composé (3) (étape (1)) et une étape de conversion de l'OH du composé résultant (2) en OR'' (étape (2)). L'étape (1) consiste à faire réagir un ester formique ou orthoformique en la présente d'un acide de Lewis et d'une base. L'étape (2) consiste [1] à faire réagir le composé (2) avec R''OH ou avec R''OH et CH(OR'')3 dans des conditions acides ou [2] à utiliser un catalyseur à transfert de phase dans un système à deux phases et à réguler la base ainsi que sa concentration pour synthétiser le composé cible de manière stéréosélective. Dans un autre procédé, le composé (1) est produit efficacement sans isoler le composé (2). Dans encore un autre procédé, le composé (1) est produit directement sans passer par le composé (2).
Also published as
US09869458
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