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1. WO2000040272 - P450 / ACETAMINOPHEN GDEPT FOR CANCER TREATMENT

Publication Number WO/2000/040272
Publication Date 13.07.2000
International Application No. PCT/GB1999/004269
International Filing Date 30.12.1999
Chapter 2 Demand Filed 19.07.2000
IPC
A61K 31/167 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 38/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
44Oxidoreductases (1)
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
CPC
A61K 31/167
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 38/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
44Oxidoreductases (1)
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants
  • ML LABORATORIES PLC [GB/GB]; 17 Hanover Square London W1R 9AJ, GB (AllExceptUS)
  • DAVIES, Donald [GB/GB]; GB (UsOnly)
Inventors
  • DAVIES, Donald; GB
Agents
  • HARRISON GODDARD FOOTE; Tower House Merrion Way Leeds LS2 8PA, GB
Priority Data
9900009.304.01.1999GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) P450 / ACETAMINOPHEN GDEPT FOR CANCER TREATMENT
(FR) THERAPIE GENIQUE 2
Abstract
(EN)
The invention herein described relates to a form of cancer therapy which exploits the cytotoxic properties of acetaminophen when converted to NABQI by the metabolic activity of tumour cell specific P450; vectors for use in the delivery of P450 to tumour cells; and therapeutic compositions comprising said vectors.
(FR)
L'invention ci-décrite concerne une forme de thérapie du cancer exploitant les propriétés cytotoxiques de l'acétaminophène une fois converti en NABQI par l'activité métabolique de la P450 spécifique aux cellules tumorales; des vecteurs destinés à être utilisés dans l'administration de P450 à des cellules tumorales; et des compositions thérapeutiques contenant lesdits vecteurs.
Also published as
Latest bibliographic data on file with the International Bureau