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1. WO2000040262 - NOVEL AGENTS AND METHODS FOR TREATMENT AND DIAGNOSIS OF OCULAR DISORDERS

Publication Number WO/2000/040262
Publication Date 13.07.2000
International Application No. PCT/AU1999/001163
International Filing Date 24.12.1999
Chapter 2 Demand Filed 12.07.2000
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/2812
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2812against CD4
C07K 2317/53
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
53Hinge
C07K 2317/622
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
60characterized by non-natural combinations of immunoglobulin fragments
62comprising only variable region components
622Single chain antibody (scFv)
C07K 2317/624
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
60characterized by non-natural combinations of immunoglobulin fragments
62comprising only variable region components
624Disulfide-stabilized antibody (dsFv)
Applicants
  • THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA [AU/AU]; Sturt Road Bedford Park, S.A. 5042, AU (AllExceptUS)
  • THIEL, Michael, Alexander [CH/AU]; AU (UsOnly)
  • ZOLA, Heddy [AU/AU]; AU (UsOnly)
  • COSTER, Douglas, John [AU/AU]; AU (UsOnly)
  • WILLIAMS, Keryn, Anne [AU/AU]; AU (UsOnly)
Inventors
  • THIEL, Michael, Alexander; AU
  • ZOLA, Heddy; AU
  • COSTER, Douglas, John; AU
  • WILLIAMS, Keryn, Anne; AU
Agents
  • ARGAET, Victor ; Davies Collison Cave 1 Little Collins Street Melbourne, VIC 3000, AU
Priority Data
PP 803305.01.1999AU
PQ 330507.10.1999AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL AGENTS AND METHODS FOR TREATMENT AND DIAGNOSIS OF OCULAR DISORDERS
(FR) NOUVEAUX AGENTS ET METHODES POUR LE TRAITEMENT ET LE DIAGNOSTIC DE TROUBLES OCULAIRES
Abstract
(EN)
A method of treating an ocular disorder is disclosed, comprising administering to a patient in need of such treatment, an effective amount of a sub-immunoglobulin antigen-binding molecule that is immuno-interactive with a target antigen associated with the disorder. The invention is also directed to compositions comprising this sub-immunoglobulin antigen-binding molecule and to a method of diagnosing an ocular condition using such molecule.
(FR)
L'invention concerne une méthode de traitement d'un trouble oculaire, qui consiste à administrer à un patient en ayant besoin, une dose efficace d'une molécule de liaison à l'antigène des sous-immunoglobulines, qui interagit avec un antigène cible associé au trouble. L'invention porte également sur des compositions comprenant ladite molécule de liaison à l'antigène des sous-immunoglobulines, et sur une méthode de diagnostic d'un état oculaire, au moyen de ladite molécule.
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