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1. WO2000040261 - VACCINATION METHOD FOR EFFICIENT INDUCTION OF CYTOTOXIC T LYMPHOCYTE RESPONSE

Publication Number WO/2000/040261
Publication Date 13.07.2000
International Application No. PCT/US2000/000286
International Filing Date 06.01.2000
Chapter 2 Demand Filed 31.07.2000
IPC
A61K 39/21 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
A61K 39/29 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
29Hepatitis virus
A61K 39/385 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
385Haptens or antigens, bound to carriers
CPC
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
A61K 2039/6075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
6075Viral proteins
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
Applicants
  • WISCONSIN ALUMNI RESEARCH FOUNDATION [US/US]; 614 Walnut Street Madison, WI 53705, US (AllExceptUS)
  • POWDERJECT VACCINES, INC. [US/US]; 585 Science Drive Madison, WI 53711, US (AllExceptUS)
  • WATKINS, David, I. [US/US]; US (UsOnly)
  • ALLEN, Todd, M. [US/US]; US (UsOnly)
  • VOGEL, Thorsten, U. [US/US]; US (UsOnly)
  • FULLER, Deborah, L. [US/US]; US (UsOnly)
  • FULLER, James, T. [US/US]; US (UsOnly)
Inventors
  • WATKINS, David, I.; US
  • ALLEN, Todd, M.; US
  • VOGEL, Thorsten, U.; US
  • FULLER, Deborah, L.; US
  • FULLER, James, T.; US
Agents
  • BAKER, Jean, C.; Quarles & Brady LLP 411 East Wisconsin Avenue Milwaukee, WI 53202-4497, US
Priority Data
60/115,40508.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VACCINATION METHOD FOR EFFICIENT INDUCTION OF CYTOTOXIC T LYMPHOCYTE RESPONSE
(FR) METHODE DE VACCINATION VISANT A L'INDUCTION EFFICACE D'UNE REPONSE AUX LYMPHOCYTES T CYTOTOXIQUES
Abstract
(EN)
A method for inducing an epitope-specific cytotoxic lymphocyte response in primates is disclosed. The method involves delivering a DNA-based vaccine that encodes an MHC class I epitope and a polyepitope and an MHC class I epitope and the hepatitis B core antigen into the primate, followed by delivering a modified virus vaccine that encodes an MHC class I epitope and a polyepitope into the primate.
(FR)
La présente invention concerne une méthode visant à induire une réponse aux lymphocytes cytotoxiques spécifiques à l'épitope chez des primates. Cette méthode consiste à administrer au primate un vaccin à base d'ADN qui code un épitope de classe I à complexe majeur d'histocompatibilité (CMH) et un polyépitope, ainsi qu'un épitope de classe I CMH et un antigène capsidique de l'hépatite B, puis à administrer au primate un vaccin à base de virus modifié qui code un épitope de classe I CMH et un polyépitope.
Also published as
US09869753
Latest bibliographic data on file with the International Bureau