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1. WO2000040236 - STABILE AND STERILE EMULSION WHICH CONTAINS TAXANES, AND METHOD FOR THE PRODUCTION THEREOF

Publication Number WO/2000/040236
Publication Date 13.07.2000
International Application No. PCT/EP2000/000007
International Filing Date 03.01.2000
Chapter 2 Demand Filed 03.08.2000
IPC
A61K 9/107 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
A61K 31/337 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
337having four-membered rings, e.g. taxol
A61K 47/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42107; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
CPC
A61K 31/337
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
337having four-membered rings, e.g. taxol
A61K 47/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61K 9/1075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions ; ; Emulsion preconcentrates; Micelles
1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Applicants
  • DIETL, Hans [DE/DE]; DE
Inventors
  • DIETL, Hans; DE
Agents
  • BEHNISCH, Werner; Reinhard, Skuhra, Weise & Partner GbR Postfach 44 01 51 D-80750 München, DE
Priority Data
199 00 054.904.01.1999DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) TAXANE ENTHALTENDE STABILE UND STERILE EMULSION UND VERFAHREN ZU IHRER HERSTELLUNG
(EN) STABILE AND STERILE EMULSION WHICH CONTAINS TAXANES, AND METHOD FOR THE PRODUCTION THEREOF
(FR) EMULSION STERILE ET STABLE CONTENANT DES TAXANES ET SON PROCEDE DE PRODUCTION
Abstract
(DE)
Die vorliegende Erfindung offenbart ein Verfahren zur Herstellung einer Taxane enthaltenden pharmazeutischen Zubereitung in Form einer stabilen und sterilen Öl-in-Wasser Emulsion, die dadurch gekennzeichnet ist, daß sie zumindest ein Taxan, zumindest ein Triglycerid von Fettsäuren mit 4-24 Kohlenstoffatomen, 3-sn-Phosphatidylcholin und/oder Phosphatidylethanolamin, Alkalisalze freier Fettsäuren und Wasser, jedoch im wesentlichen keine synthetischen nicht-ionischen Emulgatoren, enthält.
(EN)
The invention relates to a method for producing a pharmaceutical preparation which contains taxanes and which is provided in the form of a stabile and sterile oil-in-water emulsion. The oil-in-water emulsion is characterized in that it contains at least one taxane, at least one triglyceride of fatty acids with 4-24 carbon atoms, 3-sn-phosphatidylcholine and/or phosphatidylethanolamine, alkaline-salts of free fatty acids, and water. However, said oil-in-water emulsion contains essentially no synthetic non-ionic emulsifiers.
(FR)
L'invention concerne un procédé pour la production d'une préparation pharmaceutique contenant des taxanes, sous forme d'une émulsion de type aqueux stérile et stable. La préparation selon l'invention est caractérisée en ce qu'elle contient au moins un taxane, au moins un triglycéride d'acides gras ayant 4 à 24 atomes de carbone, de la 3-sn-phosphatidylcholine ou de la phosphatidyléthanolamine, des sels d'alcalis d'acides gras libres et de l'eau, mais pratiquement pas d'émulsifiants non ioniques synthétiques.
Also published as
Latest bibliographic data on file with the International Bureau