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1. WO2000040220 - METHOD OF PREPARING PHARMACEUTICAL ACTIVE INGREDIENT COMPRISING WATER-INSOLUBLE DRUG AND PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION COMPRISING THE SAME

Publication Number WO/2000/040220
Publication Date 13.07.2000
International Application No. PCT/KR1999/000025
International Filing Date 06.01.1999
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 9/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
CPC
A61K 9/1635
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1635obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
A61K 9/1641
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1641obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
A61K 9/1652
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
A61K 9/4858
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4841Filling excipients; Inactive ingredients
4858Organic compounds
Applicants
  • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY [KR/KR]; 100, Jang-dong Yuseong-ku Daejeon-city 305-343, KR (AllExceptUS)
  • YUK, Soon-Hong [KR/KR]; KR (UsOnly)
  • CHO, Sun-Hang [KR/KR]; KR (UsOnly)
  • LEE, Hai-Bang [KR/KR]; KR (UsOnly)
Inventors
  • YUK, Soon-Hong; KR
  • CHO, Sun-Hang; KR
  • LEE, Hai-Bang; KR
Agents
  • KIM, Won-Ho; 702, Teheran Building 825-33 Yoksam-dong Kangnam-ku Seoul 135-080, KR
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF PREPARING PHARMACEUTICAL ACTIVE INGREDIENT COMPRISING WATER-INSOLUBLE DRUG AND PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION COMPRISING THE SAME
(FR) PROCEDE DE PREPARATION D'UN PRINCIPE ACTIF PHARMACEUTIQUE CONTENANT UN MEDICAMENT NON HYDROSOLUBLE ET COMPOSITION PHARMACEUTIQUE POUR L'ADMINISTRATION ORALE CONTENANT LEDIT PRINCIPE
Abstract
(EN)
A method of preparing a pharmaceutical active ingredient comprising a water-insoluble drug is provided. In the method, a water-insoluble drug in an organic solvent is mixed with a water-soluble polymer in an aqueous solvent and spray-dried. Thereafter, the drug microparticles is mixed with oil. The method can easily prepare a pharmaceutical active ingredient including water-insoluble drug, exhibiting good bioavailability. Accordingly, it is not required for specific technology in the preparation.
(FR)
Procédé de préparation d'un principe actif pharmaceutique contenant un médicament non hydrosoluble. Selon ledit procédé, un médicament non hydrosoluble se trouvant dans un solvant organique est mélangé avec un polymère hydrosoluble se trouvant dans un solvant aqueux et séché par atomisation. Ensuite, les microparticules de médicament sont mélangées à de l'huile. Ledit procédé permet de préparer facilement un principe actif pharmaceutique contenant un médicament non hydrosoluble, qui possède une excellente biodisponibilité. Par conséquent, la préparation dudit principe ne nécessite pas une technologie spécifique.
Also published as
US09623286
Latest bibliographic data on file with the International Bureau