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1. WO2000039716 - ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS

Publication Number WO/2000/039716
Publication Date 06.07.2000
International Application No. PCT/GB1999/004308
International Filing Date 17.12.1999
Chapter 2 Demand Filed 08.06.2000
IPC
C07D 233/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
C07D 521/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
521Heterocyclic compounds containing unspecified hetero rings
CPC
C07D 231/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 233/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
56with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
C07D 233/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
64with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
C07D 249/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Applicants
  • ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje, SE (AllExceptUS)
  • ARNOULD, Jean-Claude [FR/FR]; FR (UsOnly)
  • OLIVIER, Annie, Antoinette, Christiane [FR/FR]; FR (UsOnly)
Inventors
  • ARNOULD, Jean-Claude; FR
  • OLIVIER, Annie, Antoinette, Christiane; FR
Agents
  • BROWN, Andrew, Stephen; Global Intellectual Property AstraZeneca P.O. Box 272, Mereside Alderley Park, Macclesfield Cheshire SK10 4GR, GB
Priority Data
98403279.723.12.1998EP
98403280.523.12.1998EP
98403281.323.12.1998EP
99400297.009.02.1999EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS
(FR) COMPOSES CHIMIQUES
Abstract
(EN)
This invention relates to compounds of formula (1), wherein substituents are defined in the description, that inhibit farnesylation of mutant ras gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation of ras.
(FR)
Cette invention porte sur des composés chimiques de la formule (1) dans laquelle des substituants tels que définis dans la demande inhibent la farnesylation de produits géniques mutants ras par inhibition de l'enzyme farnesyl-protéine transférase (FPTase). Cette invention porte également sur des procédés de fabrication de ces composés, sur des compositions pharmaceutiques et sur des procédés de traitement de maladies telles que le cancer qui sont induites par farnesylation de ras.
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