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1. WO2000039585 - IDENTIFYING SMALL ORGANIC MOLECULE LIGANDS FOR BINDING

Publication Number WO/2000/039585
Publication Date 06.07.2000
International Application No. PCT/US1999/030960
International Filing Date 23.12.1999
Chapter 2 Demand Filed 21.07.2000
IPC
C07B 61/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61Other general methods
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
C40B 40/00
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
G01N 2500/20
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
20cell-free systems
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
Applicants
  • SUNESIS PHARMACEUTICALS, INC. [US/US]; Suite C 3696 Haven Avenue Redwood City, CA 94063, US
Inventors
  • WELLS, Jim; US
  • BALLINGER, Marcus; US
  • CUNNINGHAM, Brian, C.; US
Agents
  • BREZNER, David, J. ; Flehr, Hohbach, Test, Albritton & Herbert LLP 4 Embarcadero Center Suite 3400 San Francisco, CA 94111-4187, US
Priority Data
09/221,75928.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IDENTIFYING SMALL ORGANIC MOLECULE LIGANDS FOR BINDING
(FR) IDENTIFICATION DE LIGANDS DE TYPE PETITES MOLECULES ORGANIQUES, DESTINES A FORMER DES LIAISONS
Abstract
(EN)
The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules, wherein those methods take advantage of principles of binding avidity. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like. Biological target molecules include, for example, polypeptides, nucleic acids, carbohydrates, nucleoproteins, glycoproteins, glycolipids and lipoproteins.
(FR)
La présente invention se rapporte à de nouvelles méthodes d'identification rapide et sans ambiguïté de petites molécules organiques qui sont des ligands susceptibles de se lier à des molécules biologiques cibles, lesdites méthodes s'appuyant sur certains principes d'avidité de liaison. Les petites molécules organiques ligands identifiées conformément aux méthodes de cette invention peuvent être utilisées, par exemple, en tant que nouveaux composés chefs de file pour le développement de médicaments thérapeutiques, inhibiteurs d'enzymes, composés de marquage, réactifs de diagnostic, réactifs d'affinité pour la purification de protéines et analogues. Les molécules biologiques cibles incluent, par exemple, des polypeptides, des acides nucléiques, des carbohydrates, des nucléoprotéines, des glycoprotéines, des glycolipides et des lipoprotéines.
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