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1. WO2000039332 - GENOTYPING CYTOCHROME EXPRESSION

Publication Number WO/2000/039332
Publication Date 06.07.2000
International Application No. PCT/GB1999/004380
International Filing Date 22.12.1999
Chapter 2 Demand Filed 29.05.2000
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • JANSSEN PHARMACEUTICA N.V. [BE/BE]; Turnhoutseweg 30 B-2340 Beerse, BE (AllExceptUS)
  • PAULUSSEN, Aimee, Dymphne, Catherine [NL/BE]; BE (UsOnly)
  • ARMSTRONG, Martin [GB/GB]; GB (UsOnly)
Inventors
  • PAULUSSEN, Aimee, Dymphne, Catherine; BE
  • ARMSTRONG, Martin; GB
Agents
  • BOULT WADE TENNANT; Verulam Gardens 70 Gray's Inn Road London WC1X 8BT, GB
Priority Data
9828619.823.12.1998GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GENOTYPING CYTOCHROME EXPRESSION
(FR) GENOTYPAGE DE L'EXPRESSION DU CYTOCHROME
Abstract
(EN)
There is disclosed a method of identifying subjects having a high or low drug metabolising phenotype associated with cytochrome CYP3A5 expression, which method comprises screening genomic DNA from said subject for the presence or absence of one or more polymorphic variants in a transcription regulatory region of the sequence encoding CYP3A5. Oligonucleotide molecules for carrying out the screening are also provided.
(FR)
L'invention se rapporte à un procédé d'identification de sujets présentant un phénotype de métabolisation élevée ou faible du médicament associé à l'expression du cytochrome CYP3A5. Le procédé consiste à cribler l'ADN génomique prélevé chez le sujet afin de déterminer la présence ou l'absence d'un ou plusieurs variants polymorphes dans une région régulatrice de la transcription de la séquence codant CYP3A5. L'invention se rapporte également à des molécules oligonucléotidiques servant à effectuer le criblage.
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