Processing

Please wait...

Settings

Settings

1. WO2000039317 - GENE TRANSFER VECTOR FOR THE DIAGNOSIS AND THERAPY OF MALIGN TUMORS

Publication Number WO/2000/039317
Publication Date 06.07.2000
International Application No. PCT/DE1999/004099
International Filing Date 27.12.1999
Chapter 2 Demand Filed 20.07.2000
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 15/861 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
861Adenoviral vectors
CPC
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 2710/10343
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
10011Adenoviridae
10311Mastadenovirus, e.g. human or simian adenoviruses
10341Use of virus, viral particle or viral elements as a vector
10343viral genome or elements thereof as genetic vector
C12N 2830/008
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2830Vector systems having a special element relevant for transcription
008cell type or tissue specific enhancer/promoter combination
Applicants
  • MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN [DE/DE]; Robert-Rössle-Strasse 10 D-13125 Berlin, DE (AllExceptUS)
  • WOLFF, Gerhard [DE/DE]; DE (UsOnly)
  • ROYER, Hans-Dieter [DE/DE]; DE (UsOnly)
  • WOISCHWILL, Christiane [DE/DE]; DE (UsOnly)
  • JANZ, Martin [DE/DE]; DE (UsOnly)
  • SCHUMACHER, Axel [DE/DE]; DE (UsOnly)
  • DÖRKEN, Bernd [DE/DE]; DE
Inventors
  • WOLFF, Gerhard; DE
  • ROYER, Hans-Dieter; DE
  • WOISCHWILL, Christiane; DE
  • JANZ, Martin; DE
  • SCHUMACHER, Axel; DE
  • DÖRKEN, Bernd; DE
Agents
  • BAUMBACH, Fritz; Robert-Rössle-Strasse 10 D-13125 Berlin, DE
Priority Data
198 60 602.829.12.1998DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) GENTRANSFERVEKTOR FÜR DIE DIAGNOSTIK UND DIE THERAPIE VON MALIGNEN TUMOREN
(EN) GENE TRANSFER VECTOR FOR THE DIAGNOSIS AND THERAPY OF MALIGN TUMORS
(FR) VECTEUR DE TRANSFERT DE GENES DESTINE AU DIAGNOSTIC ET THERAPIE DE TUMEURS MALIGNES
Abstract
(DE)
Die Erfindung betrifft einen Gentransfervektor für die Diagnostik und die Therapie von malignen Tumoren, der für ein beliebiges Transgen unter Kontrolle des tumorspezifischen YB-1 Promotors kodiert. Er besteht aus dem YB-1 Promotor, einem Transgen und zwei zum Herausschneiden des Transgens geeigneten 'Multiple cloning sites' für Restriktionsenzyme, die das Transgen umgeben. In das Konstrukt kann ein beliebiges Gen hineinkloniert werden, um gewebsspezifisch in chemoresistenten Tumorzellen exprimiert zu werden.
(EN)
The invention relates to a gene transfer vector for the diagnosis and the therapy of malign tumors which codes for any transgene under the control of the tumor-specific YB-1 promoter. Said transgenic vector consists of the YB-1 promoter, a transgene and two multiple cloning sites for restriction enzymes that surround the transgene which cloning sites are suitable for cutting out the transgene. Any gene can be cloned into the construct for its tissue-specific expression in chemo-resistant tumor cells.
(FR)
L'invention concerne un vecteur de transfert de gènes destiné au diagnostic et la thérapie de tumeurs malignes. Ce vecteur est codé pour un transgène quelconque sous le contrôle du promoteur YB-1 spécifique à la tumeur. Il est constitué du promoteur YB-1, d'un transgène et de deux sites de clonage multiples adaptés au découpage du transgène et destinés à des enzymes de restriction qui entourent le transgène. Un gène quelconque peut être cloné dans la construction pour être exprimé dans des cellules tumorales chémorésistantes de façon spécifique au tissu.
Also published as
US09869508
Latest bibliographic data on file with the International Bureau