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1. WO2000039310 - RUBREDOXIN FUSION PROTEINS, PROTEIN EXPRESSION SYSTEM AND METHODS

Publication Number WO/2000/039310
Publication Date 06.07.2000
International Application No. PCT/US1999/031176
International Filing Date 29.12.1999
Chapter 2 Demand Filed 28.07.2000
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/195 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/575 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
C07K 14/62 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
62Insulins
C07K 14/72 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
72for hormones
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/195
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
C07K 14/4711
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4711Alzheimer's disease; Amyloid plaque core protein
C07K 14/5759
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
5759Products of obesity genes, e.g. leptin, obese (OB), tub, fat
C07K 14/62
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
62Insulins
C07K 14/723
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
72for hormones
723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
Applicants
  • THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US/US]; Boyd Graduate Studies Research Center Athens, GA 30602-7411, US (AllExceptUS)
  • PRZYBYLA, Alan [US/US]; US (UsOnly)
  • MENON, Nanda [IN/US]; US (UsOnly)
Inventors
  • PRZYBYLA, Alan; US
  • MENON, Nanda; US
Agents
  • SANDBERG, Victoria, A.; Mueting, Raasch & Gebhardt, P.A. P.O. Box 581415 Minneapolis, MN 55458-1415, US
Priority Data
60/114,03429.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RUBREDOXIN FUSION PROTEINS, PROTEIN EXPRESSION SYSTEM AND METHODS
(FR) PROTEINES HYBRIDES DE RUBREDOXINE, SYSTEME ET METHODES D'EXPRESSION DE PROTEINE
Abstract
(EN)
A recombination fusion protein is presented which comprises rubredoxin as the fusion partner. The fusion protein optionally includes an intervening spacer region between the rubredoxin constituent and the fused polypeptide of interest that can contain a proteolytic cleavage site for release of the polypeptide of interest. The fusion protein can contain one or more sites for affinity purification. The invention also includes methods and materials for making and using the rubredoxin fusion protein. Also provided are antigenic compounds and compositions, including vaccines, comprising a rubredoxin as a carrier molecule linked to an antigen or hapten.
(FR)
Cette invention a trait à une nouvelle protéine hybride de recombinaison comprenant de la rubrédoxine comme partenaire de fusion. Cette protéine hybride peut, éventuellement, comprendre une région d'espacement intervenante entre le constituant rubrédoxine et le polypeptide fusionné étudié, pouvant comporter un site de clivage protéolytique pour la libération dudit polypeptide. Cette protéine hybride peut contenir un ou plusieurs sites pour purification par affinité. L'invention concerne également des méthodes et des substances permettant de produire et d'utiliser la protéine hybride rubrédoxine. Elle porte, en outre, sur des composés et des compositions antigéniques, notamment des vaccins, renfermant la rubrédoxine comme molécule porteuse liée à un antigène ou à un haptène.
Also published as
US09869446
Latest bibliographic data on file with the International Bureau