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1. WO2000039290 - PHARMACEUTICAL FORMULATION CONTAINING A MICROBIAL ENZYME WHICH DIGESTS HYALURONIC ACID

Publication Number WO/2000/039290
Publication Date 06.07.2000
International Application No. PCT/DE1999/004108
International Filing Date 22.12.1999
IPC
A61K 38/51 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
51Lyases (4)
C12N 9/88 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88Lyases (4.)
CPC
A61K 38/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
51Lyases (4)
C12N 9/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
88Lyases (4.)
C12Y 402/02001
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
402Carbon-oxygen lyases (4.2)
02acting on polysaccharides (4.2.2)
02001Hyaluronate lyase (4.2.2.1)
Applicants
  • ID PHARMA GMBH [DE/DE]; Markt 2 D-07743 Jena, DE (AllExceptUS)
  • PRESSELT, Norbert [DE/DE]; DE (UsOnly)
  • MÜLLER, Peter-Jürgen [DE/DE]; DE (UsOnly)
  • OZEGOWSKI, Jörg-Hermann [DE/DE]; DE (UsOnly)
  • HÄRTL, Albert [DE/DE]; DE (UsOnly)
  • PESCHEL, Gundela [DE/DE]; DE (UsOnly)
Inventors
  • PRESSELT, Norbert; DE
  • MÜLLER, Peter-Jürgen; DE
  • OZEGOWSKI, Jörg-Hermann; DE
  • HÄRTL, Albert; DE
  • PESCHEL, Gundela; DE
Agents
  • STÖRLE, Christian ; Geyer, Fehners & Partner (G.b.R.) Perhamerstrasse 31 D-80687 München, DE
Priority Data
198 60 541.223.12.1998DE
198 60 542.023.12.1998DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) PHARMAZEUTISCHE FORMULIERUNG ENTHALTEND EIN HYALURONSÄURE-SPALTENDES ENZYM MIKROBIELLER HERKUNFT
(EN) PHARMACEUTICAL FORMULATION CONTAINING A MICROBIAL ENZYME WHICH DIGESTS HYALURONIC ACID
(FR) FORMULATION PHARMACEUTIQUE CONTENANT UN ENZYME DECOMPOSANT L'ACIDE HYALURONIQUE ET D'ORIGINE MICROBIENNE
Abstract
(DE)
Die Erfindung beinhaltet pharmazeutische Formulierungen, welche insbesondere geeignet sind als Injektionspräparate mit einer therapeutischen Anwendung bei Gefässkrankheiten, die als Folge von atheromatösen Ablagerungen auf den Innenwänden der Arterien auftreten. Die Injektionspräparate enthalten eine Hyaluronatlyase bakterieller Herkunft bzw. ein aus diesem Enzym hergestelltes hyaluronatspaltendes Enzymfragment. Das hyaluronatspaltende Enzymfragment der bakteriellen Hyaluronatlyase ist ebenfalls Gegenstand der Erfindung. Es kann hergestellt werden, indem das Holoenzym mit einer spezifisch spaltenden Protease behandelt wird.
(EN)
The invention relates to pharmaceutical compositions which are especially suitable as injection preparations to be used for the therapy of vascular diseases which are caused by atheromatous deposits on the inner walls of arteria. Said injection preparations contain bacterial hyaluronate lyase or a hyaluronate-digesting enzyme fragment produced from said enzyme. The invention also relates to the hyaluronate-digesting enzyme fragment of the bacterial hyaluronate lyase. It may be produced by treating the holoenzyme with a specifically digesting protease.
(FR)
L'invention concerne des formulations pharmaceutiques particulièrement adaptées comme préparations d'injection ayant une application thérapeutique dans le cas des maladies vasculaires apparaissant à la suite de dépôts athéromateux sur les parois internes des artères. Ces préparations d'injection contiennent une lyase d'hyaluronate d'origine bactérienne ou un fragment enzymatique dissociant l'hyaluronate et produit à partir de cet enzyme. L'invention concerne également le fragment enzymatique dissociant l'hyaluronate de la lyase d'hyaluronate bactérienne. On peut l'obtenir par traitement de l'holoenzyme avec une protéase spécifique.
Also published as
CZPV2000-3061
DE19982882
US09622879
Latest bibliographic data on file with the International Bureau