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1. WO2000039165 - SERINE PROTEASE INHIBITOR

Publication Number WO/2000/039165
Publication Date 06.07.2000
International Application No. PCT/NZ1999/000227
International Filing Date 23.12.1999
Chapter 2 Demand Filed 13.07.2000
IPC
A23J 1/04 2006.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
1Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
04from fish or other sea animals
A23L 1/305 2006.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1Foods or foodstuffs; Their preparation or treatment
29Modifying nutritive qualities of foods; Dietetic products
30containing additives
305Amino acids, peptides or proteins 
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/435 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
C07K 14/81 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81Protease inhibitors
CPC
A23J 1/04
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
1Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
04from fish or other sea animals
A23L 33/17
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
17Amino acids, peptides or proteins
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/43504
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
C07K 14/811
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81Protease inhibitors
8107Endopeptidase (E.C. 3.4.21-99) inhibitors
811Serine protease (E.C. 3.4.21) inhibitors
Applicants
  • THE HORTICULTURE AND FOOD RESEARCH INSTITUTE OF NEW ZEALAND LIMITED [NZ/NZ]; Batchelar Research Centre Highway 57 Palmerston North, NZ (AllExceptUS)
  • SCOTTI, Paul, Douglas [NZ/NZ]; NZ (UsOnly)
  • DEARING, Sally, Caroline [NZ/NZ]; NZ (UsOnly)
  • GREENWOOD, David, Roger [NZ/NZ]; NZ (UsOnly)
  • NEWCOMB, Richard, David [NZ/NZ]; NZ (UsOnly)
Inventors
  • SCOTTI, Paul, Douglas; NZ
  • DEARING, Sally, Caroline; NZ
  • GREENWOOD, David, Roger; NZ
  • NEWCOMB, Richard, David; NZ
Agents
  • WEST-WALKER, Gregory, James; A J Park Huddart Parker Building, 6th floor 1 Post Office Square P.O. Box 949 Wellington 6015, NZ
Priority Data
33356823.12.1998NZ
33690623.07.1999NZ
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SERINE PROTEASE INHIBITOR
(FR) INHIBITEUR DE SERINE PROTEASE
Abstract
(EN)
The invention provides a protein which exhibits, $i(inter alia), anti-thrombin activity and divalent metal cation binding activity. The protein can be readily extracted from the green-lipped mussell, $i(Perna canaliculus), and formulated into foodstuffs, nutraceuticals and the like, and has a molecular weight of about 55 kDa and an amino acid sequence which includes one or more of the following: (a) DGEQCNDGQN (SEQ ID NO.1), (b) QGGHEVESERVACCVIGRA (SEQ ID NO. 2), (c) GQSHPEIVH (SEQ ID NO. 3), (d) YHGHDDA (SEQ ID NO. 4), (e) VVNEVHH (SEQ ID NO. 5)
(FR)
L'invention concerne une protéine présentant, entre autres, une activité antithrombotique et une activité de fixation de cations métalliques divalents. Cette protéine peut être obtenue facilement à partir de moules de Nouvelle Zélande, $i(Perna canaliculus), et formulée dans des produits alimentaires, des aliments fonctionnels et analogues; et elle possède un poids moléculaire d'environ 55 kDa, ainsi qu'une séquence d'acides aminés comportant une ou plusieurs parmi les suivantes: (a) DGEQCNDGQN (SEQ ID NO.1), (b) QGGHEVESERVACCVIGRA (SEQ ID NO. 2), (c) GQSHPEIVH (SEQ ID NO. 3), (d) YHGHDDA (SEQ ID NO. 4), (e) VVNEVHH (SEQ ID NO. 5)
Also published as
NZ512021
US09868760
Latest bibliographic data on file with the International Bureau