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1. WO2000039153 - PSEUDOPEPTIDE COMPOUNDS HAVING AN INHIBITING ACTIVITY WITH RESPECT TO PATHS ACTIVATED BY PROTEINS WITH ACTIVE TYROSINE KINASE ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Publication Number WO/2000/039153
Publication Date 06.07.2000
International Application No. PCT/FR1999/003289
International Filing Date 24.12.1999
Chapter 2 Demand Filed 07.07.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
C07K 5/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
C07K 14/71 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/71
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
C07K 5/021
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
021containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
C07K 5/0827
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0827containing heteroatoms different from O, S, or N
Applicants
  • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSERM [FR/FR]; 101, rue de Tolbiac F-75013 Paris, FR (AllExceptUS)
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS [FR/FR]; 3, rue Michel Ange F-75016 Paris, FR (AllExceptUS)
  • GARBAY, Christiane [FR/FR]; FR (UsOnly)
  • LIU, Wang-Qing [CN/FR]; FR (UsOnly)
  • VIDAL, Michel [FR/FR]; FR (UsOnly)
  • ROQUES, Bernard, P. [FR/FR]; FR (UsOnly)
Inventors
  • GARBAY, Christiane; FR
  • LIU, Wang-Qing; FR
  • VIDAL, Michel; FR
  • ROQUES, Bernard, P.; FR
Agents
  • MONCHENY, Michel; Cabinet Lavoix 2, place d'Estienne d'Orves F-75441 Paris Cedex 09, FR
Priority Data
98/1645924.12.1998FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) PSEUDOPEPTIDE COMPOUNDS HAVING AN INHIBITING ACTIVITY WITH RESPECT TO PATHS ACTIVATED BY PROTEINS WITH ACTIVE TYROSINE KINASE ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
(FR) COMPOSES PSEUDOPEPTIDIQUES DOTES D'UNE ACTIVITE INHIBITRICE A L'EGARD DES VOIES ACTIVEES PAR LES PROTEINES A ACTIVITE TYROSINE KINASE ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
Abstract
(EN)
The invention concerns a compound corresponding to general formula (I) wherein, in particular: R2 represents a phenylmethyl or naphthylmethyl or cyclohexylmethyl radical, 2- and 3-pyridinylmethyl, substituted on the cycle in meta or para position by an acid group or an alkyl radical of the type (CH2)n (with n = 3 or 4) substituted in terminal position by an acid group; and R3 represents a hydrogen group or a linear or branched C1-C4 alkyl or alkylcycloalkyl with a C3-C6 cycloalkyl. The invention also concerns the use of a compound of general formula (I) for preparing a pharmaceutical composition for treating diseases related to proliferative processes, cancers and/or metastases.
(FR)
L'invention a pour objet un composé répondant à la formule générale (I) dans laquelle notamment: R2 représente un radical phénylméthyle ou naphtylméthyle ou cyclohexylméthyle, 2- et 3-pyridinylméthyle, substitué sur le cycle en position para ou méta par un groupement acide ou un radical alkyle de type (CH2)n (avec n = 3 ou 4) substitué en position terminale par un groupement acide; et R3 représente un groupement hydrogène ou alkyle en C1 à C4, linéaire ou ramifié ou alkylcycloalkyle avec un cycloalkyle en C3 à C6. Elle a également pour objet l'utilisation d'un composé de formule générale (I) pour la préparation d'une composition pharmaceutique destinée au traitement des maladies liées à des processus prolifératifs, des cancers et/ou métastases.
Also published as
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