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1. WO2000039151 - NEUTRALIZING ASSAY USING HUMAN PAPILLOMAVIRUS VIRUS-LIKE PARTICLES

Publication Number WO/2000/039151
Publication Date 06.07.2000
International Application No. PCT/US1999/030297
International Filing Date 20.12.1999
Chapter 2 Demand Filed 18.07.2000
IPC
C12N 7/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12N 2710/20023
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
20011Papillomaviridae
20023Virus like particles [VLP]
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
C12Q 1/6897
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6897involving reporter genes operably linked to promoters
G01N 2333/025
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
005from viruses
01DNA viruses
025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
Applicants
  • MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US (AllExceptUS)
  • JANSEN, Kathrin, U. [DE/US]; US (UsOnly)
  • YEAGER, Mark, D. [US/US]; US (UsOnly)
  • KELLER, Paul, M. [US/US]; US (UsOnly)
  • LOWE, Robert, S. [US/US]; US (UsOnly)
  • ASTE-AMEZAGA, Miguel [PE/US]; US (UsOnly)
Inventors
  • JANSEN, Kathrin, U.; US
  • YEAGER, Mark, D.; US
  • KELLER, Paul, M.; US
  • LOWE, Robert, S.; US
  • ASTE-AMEZAGA, Miguel; US
Common Representative
  • MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US
Priority Data
60/113,38823.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEUTRALIZING ASSAY USING HUMAN PAPILLOMAVIRUS VIRUS-LIKE PARTICLES
(FR) DOSAGE NEUTRALISANT UTILISANT DES PARTICULES VERIFORMES DU PAPILLOMAVIRUS HUMAIN
Abstract
(EN)
Pseudovirions, comprised of a papilloma virus-like particle (VLP) joined to a reporter gene construct are described. The pseudovirions can be used in assays to detect the presence of anti-VLP neutralizing antibodies. Also described are processes for making the pseudovirions.
(FR)
L'invention concerne des pseudovirions comprenant une particule vériforme du papillomavirus liée à une structure de gène rapporteur. Les pseudovirions peuvent être utilisés dans des dosages pour détecter la présence d'anticorps neutralisants dirigés contre les particules vériformes. L'invention concerne aussi des processus de fabrication de ces pseudovirions.
Also published as
US09857917
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