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1. WO2000039150 - SECRETED PROTEINS AND USES THEREOF

Publication Number WO/2000/039150
Publication Date 06.07.2000
International Application No. PCT/US1999/031158
International Filing Date 29.12.1999
Chapter 2 Demand Filed 26.07.2000
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • MILLENNIUM PHARMACEUTICALS, INC. [US/US]; 75 Sidney Street Cambridge, MA 02139, US
Inventors
  • SHARP, John, D.; US
Agents
  • CORUZZI, Laura, A. ; Pennie & Edmonds LLP 1155 Avenue of the Americas New York, NY 10036, US
Priority Data
09/223,09430.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SECRETED PROTEINS AND USES THEREOF
(FR) PROTEINES SECRETEES ET LEURS UTILISATIONS
Abstract
(EN)
The invention provides isolated nucleic acid molecules, designated TANGO 221, TANGO 222, TANGO 176, and TANGO 232, which encode wholly secreted or membrane-associated proteins. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
(FR)
Cette invention a trait à des molécules d'acide nucléique isolées, désignées sous le nom de TANGO 221, TANGO 176, et TANGO 232 codant des protéines entièrement sécrétées ou associées à des membranes. Elle porte, de surcroît, sur des molécules d'acide nucléique antisens, sur des vecteurs d'expression contenant les molécules d'acide nucléique de l'invention, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques chez qui une molécule d'acide nucléique de l'invention a été introduite ou disloquée. Elle concerne, en outre, des polypeptides isolés, des polypeptides de fusion, des peptides antigéniques et des anticorps. Il est encore question, dans cette invention, de méthodes diagnostiques, de criblage et de méthodes thérapeutiques utilisant des compositions de l'invention.
Also published as
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