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1. WO2000039141 - INOSITOL-CONTAINING HEXASACCHARIDES, THEIR SYNTHESIS AND THEIR USES

Publication Number WO/2000/039141
Publication Date 06.07.2000
International Application No. PCT/GB1999/004400
International Filing Date 23.12.1999
Chapter 2 Demand Filed 06.07.2000
IPC
C07H 15/207 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
207Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
CPC
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
C07H 15/207
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
207Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
Y02P 20/55
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
20Technologies relating to chemical industry
50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
55Synthetic design, e.g. reducing the use of auxiliary or protecting groups
Applicants
  • RADEMACHER GROUP LIMITED [GB/GB]; 6 St Andrew Street London EC4A 3LX, GB (AllExceptUS)
  • MARTIN-LOMAS, Manuel [ES/ES]; ES (UsOnly)
  • MOSQUERA, Maria Flores [ES/ES]; ES (UsOnly)
  • CHIARA, Jose Luis [ES/ES]; ES (UsOnly)
Inventors
  • MARTIN-LOMAS, Manuel; ES
  • MOSQUERA, Maria Flores; ES
  • CHIARA, Jose Luis; ES
Agents
  • KIDDLE, Simon, J. ; Mewburn Ellis York House 23 Kingsway London WC2B 6HP, GB
Priority Data
9828565.323.12.1998GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INOSITOL-CONTAINING HEXASACCHARIDES, THEIR SYNTHESIS AND THEIR USES
(FR) HEXASACCHARIDES CONTENANT DE L'INOSITOL, SYNTHESE ET UTILISATIONS ASSOCIEES
Abstract
(EN)
The application relates to the design and synthesis of novel hexasaccharides of general formula (I), wherein: each R is independently selected from hydrogen, an alkyl or substituted alkyl group, an acyl or substituted acyl group, a phosphate group (PO3- or PO3H for instance) or a protecting group, or two of the R groups may be cyclic phosphate; NX group represents N3; or in the NX group, X represents one or more groups independently selected from hydrogen, alkyl or substituted alkyl, acyl or substituted acyl; NY represents a phthalimido group (NPht) or N3; or in the NY group, Y represents one or more groups independently selected from hydrogen, alkyl or substituted alkyl, acyl or substituted acyl; or a salt or derivative of said compound. Methods for synthesizing the compounds and their uses are also disclosed.
(FR)
La présente invention concerne l'élaboration et la synthèse de nouveaux hexasaccharides de formule générale (I), dans laquelle: chaque R est individuellement sélectionné dans un groupe hydrogène, alkyle ou alkyle substitué, un groupe acyle ou acyle substitué, un groupe phosphate (PO3- ou PO3H, par exemple), ou un groupe de protection, deux des groupes R pouvant être phosphate cyclique; le groupe NX représente N3; ou dans le groupe NX, X représente un ou plusieurs groupes sélectionnés individuellement parmi un hydrogène, un alkyle ou un alkyle substitué, un acyle ou un acyle substitué; NY représente un groupe phthalimido (NPht) ou N3; ou dans le groupe NY, Y représente un ou plusieurs groupes individuellement sélectionnés parmi un hydrogène, un alkyle ou un alkyle substitué, un acyle ou un acyle substitué; ou un sel ou un dérivé de ce composé . En outre, cette invention concerne des procédés de synthèse de ces composés et leurs différentes utilisations.
Also published as
US09868770
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