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1. WO2000039140 - SIASTATIN B DERIVATIVES HAVING GLYCOSIDASE INHIBITORY ACTIVITIES AND PROCESS FOR PRODUCING THE SAME

Publication Number WO/2000/039140
Publication Date 06.07.2000
International Application No. PCT/JP1999/007269
International Filing Date 24.12.1999
Chapter 2 Demand Filed 16.05.2000
IPC
C07H 7/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
7Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
02Acyclic radicals
C07H 13/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02by carboxylic acids
04having the esterifying carboxyl radicals attached to acyclic carbon atoms
CPC
C07H 13/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02by carboxylic acids
04having the esterifying carboxyl radicals attached to acyclic carbon atoms
C07H 7/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
7Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
02Acyclic radicals
Applicants
  • ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI [JP/JP]; 14-23, Kami Ohsaki 3-chome Shinagawa-ku Tokyo 141-0021, JP (AllExceptUS)
  • MEIJI SEIKA KAISHA, LTD. [JP/JP]; 4-16, Kyobashi 2-chome Chuo-ku Tokyo 104-8002, JP (AllExceptUS)
  • NISHIMURA, Yoshio [JP/JP]; JP (UsOnly)
  • SHITARA, Eiki [JP/JP]; JP (UsOnly)
  • TAKEUCHI, Tomio [JP/JP]; JP (UsOnly)
Inventors
  • NISHIMURA, Yoshio; JP
  • SHITARA, Eiki; JP
  • TAKEUCHI, Tomio; JP
Agents
  • YAGITA, Shigeru ; Bussan Building Bekkan 1-15, Nishi Shimbashi 1-chome Minato-ku Tokyo 105-0003, JP
Priority Data
10/37027725.12.1998JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) SIASTATIN B DERIVATIVES HAVING GLYCOSIDASE INHIBITORY ACTIVITIES AND PROCESS FOR PRODUCING THE SAME
(FR) DERIVES DE LA SIASTANINE B PRESENTANT DES ACTIVITES INHIBITRICES DE LA GLYCOSIDASE, ET LEUR PROCEDE DE PRODUCTION
Abstract
(EN)
Compounds represented by formulae (I), (V) and (X), which are novel siastatin B derivatives having potent glycosidase inhibitory activities, are synthesized by a novel process. The compounds of the formulae (I), (V) and (X) have potent inhibitory activities on glycosidase enzymes, in particular, N-acetylgalactosaminidase, galactosidase, glucosidase and mannosidase.
(FR)
L'invention concerne des composés représentés par les formules (I), (V) et (X), ces composés étant de nouveaux dérivés de la siastanine B présentant de puissantes activités inhibitrices de la glycosidase dont la synthèse est réalisée à l'aide d'un nouveau procédé. Les composés représentés par les formules (I), (V) et (X) possèdent de puissantes activités inhibitrices des enzymes glycosidase, en particulier, la N-acétylgalactosaminidase, la galactosidase, la glucosidase et la mannosidase.
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