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1. WO2000039127 - 1H-IMIDAZO[4,5-D]PYRIDAZIN-7-ONES, 3H-IMIDAZO[4,5-C]PYRIDIN-4-ONES AND CORRESPONDING THIONES AS CORTICOTROPIN RELEASING FACTOR (CRF) RECEPTOR LIGANDS

Publication Number WO/2000/039127
Publication Date 06.07.2000
International Application No. PCT/US1999/031325
International Filing Date 30.12.1999
Chapter 2 Demand Filed 10.07.2000
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • DU PONT PHARMACEUTICALS COMPANY [US/US]; Chestnut Run Plaza 974 Centre Road Wilmington, DE 19807, US
Inventors
  • GILLIGAN, Paul, Joseph; US
  • BAKTHAVATCHALAM, Rajagopal; US
Agents
  • RUBIN, Kenneth, B.; E.I. du Pont de Nemours and Company Legal Patent Records Center 1007 Market Street Wilmington, DE 19898, US
Priority Data
60/114,18830.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 1H-IMIDAZO[4,5-D]PYRIDAZIN-7-ONES, 3H-IMIDAZO[4,5-C]PYRIDIN-4-ONES AND CORRESPONDING THIONES AS CORTICOTROPIN RELEASING FACTOR (CRF) RECEPTOR LIGANDS
(FR) 1H-IMIDAZO[4,5-D]PYRIDAZINE-7-ONES, 3H-IMIDAZO[4,5-C]PYRIDINE-4-ONES ET THIONES CORRESPONDANTS CONVENANT COMME LIGANDS DU RECEPTEUR DE LA CORTICOLIBERINE
Abstract
(EN)
Corticotropin releasing factor (CRF) antagonists of formula (I), and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
(FR)
La présente invention, qui concerne des antagonistes de la corticolibérine représentés par la formule générale (I), concerne également leur utilisation pour le traitement, d'une part des états anxieux et dépressifs et d'autres troubles psychiatriques et neurologiques, d'autre part d'affections immunologiques, cardio-vasculaires ou à implication cardiaque, et enfin de l'hypersensibilité colique liée à des troubles psychopathologiques et au stress.
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