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1. WO2000039119 - NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Publication Number WO/2000/039119
Publication Date 06.07.2000
International Application No. PCT/US1999/027958
International Filing Date 22.12.1999
Chapter 2 Demand Filed 14.06.2000
IPC
C07D 241/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 521/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
521Heterocyclic compounds containing unspecified hetero rings
CPC
C07D 231/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 233/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
56with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
C07D 241/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
C07D 249/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road Kenilworth, NJ 07033-0530, US
  • PHARMACOPEIA, INC. [US/US]; 3000 Eastpark Boulevard Cranbury, NJ 08512, US
Inventors
  • COOPER, Alan, B.; US
  • DOLL, Ronald, J.; US
  • FERREIRA, Johan, A.; US
  • GANGULY, Ashit; US
  • GIRIJAVALLABHAN, Viyyoor, M.; US
  • TAVERAS, Arthur, G.; US
  • CHAO, Jianping; US
  • BALDWIN, John, J.; US
  • HUANG, Chia-Yu; US
  • LI, Ge; US
Agents
  • JEANETTE, Henry, C. ; Schering-Plough Corporation Patent Dept., K-6-1 1990 2000 Galloping Hill Road Kenilworth, NJ 07033-0530, US
Priority Data
09/220,31423.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
(FR) IB9902093INHIBITEURS DE FARNESYL PROTEINE TRANSFERASE
Abstract
(EN)
Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
(FR)
L'invention concerne de nouveaux composés et compositions pharmaceutiques qui sont des inhibiteurs de l'enzyme farnesyl protéine transférase. Elle concerne également un procédé servant à inhiber la fonction de Ras et, de ce fait, la croissance anormale de cellules. Ce procédé consiste à administrer le nouveau composé d'aminooxyamide à un système biologique. En particulier, ce procédé inhibe la croissance anormale de cellules chez un mammifère, tel que l'homme.
Latest bibliographic data on file with the International Bureau