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1. WO2000039117 - HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa

Publication Number WO/2000/039117
Publication Date 06.07.2000
International Application No. PCT/US1999/029887
International Filing Date 15.12.1999
Chapter 2 Demand Filed 30.06.2000
IPC
C07D 213/82 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
81Amides; Imides
82in position 3
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
CPC
C07D 213/82
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78Carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals
81Amides; Imides
82in position 3
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
Applicants
  • ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, IN 46285, US (AllExceptUS)
  • BEIGHT, Douglas, Wade [US/US]; US (UsOnly)
  • CRAFT, Trelia, Joyce [US/US]; US (UsOnly)
  • FRANCISKOVICH, Jeffry, Bernard [US/US]; US (UsOnly)
  • GOODSON, Theodore, Junior [US/US]; US (UsOnly)
  • HALL, Steven, Edward [US/US]; US (UsOnly)
  • HERRON, David, Kent [US/US]; US (UsOnly)
  • JOSEPH, Sajan, Pariyadan [IN/US]; US (UsOnly)
  • KLIMKOWSKI, Valentine, Joseph [US/US]; US (UsOnly)
  • KYLE, Jeffrey, Alan [US/US]; US (UsOnly)
  • MASTERS, John, Joseph [US/US]; US (UsOnly)
  • MENDEL, David [US/US]; US (UsOnly)
  • MILOT, Guy [CA/US]; US (UsOnly)
  • PINEIRO-NUNEZ, Marta, Maria [ES/US]; US (UsOnly)
  • SAWYER, Jason, Scott [US/US]; US (UsOnly)
  • SHUMAN, Robert, Theodore [US/US]; US (UsOnly)
  • SMITH, Gerald, Floyd [US/US]; US (UsOnly)
  • TEBBE, Anne, Louise [US/US]; US (UsOnly)
  • TINSLEY, Jennifer, Marie [US/US]; US (UsOnly)
  • WEIR, Leonard, Crayton [US/US]; US (UsOnly)
  • WIKEL, James, Howard [US/US]; US (UsOnly)
  • WILEY, Michael, Robert [US/US]; US (UsOnly)
  • YEE, Ying, Kwong [US/US]; US (UsOnly)
Inventors
  • BEIGHT, Douglas, Wade; US
  • CRAFT, Trelia, Joyce; US
  • FRANCISKOVICH, Jeffry, Bernard; US
  • GOODSON, Theodore, Junior; US
  • HALL, Steven, Edward; US
  • HERRON, David, Kent; US
  • JOSEPH, Sajan, Pariyadan; US
  • KLIMKOWSKI, Valentine, Joseph; US
  • KYLE, Jeffrey, Alan; US
  • MASTERS, John, Joseph; US
  • MENDEL, David; US
  • MILOT, Guy; US
  • PINEIRO-NUNEZ, Marta, Maria; US
  • SAWYER, Jason, Scott; US
  • SHUMAN, Robert, Theodore; US
  • SMITH, Gerald, Floyd; US
  • TEBBE, Anne, Louise; US
  • TINSLEY, Jennifer, Marie; US
  • WEIR, Leonard, Crayton; US
  • WIKEL, James, Howard; US
  • WILEY, Michael, Robert; US
  • YEE, Ying, Kwong; US
Agents
  • JACKSON, Thomas, E. ; Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285, US
Priority Data
60/113,45223.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa
(FR) AMIDES HETEROAROMATIQUES COMME INHIBITEURS DU FACTEUR Xa
Abstract
(EN)
This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
(FR)
L'invention concerne des amides hétéroaromatiques (ou un sel pharmaceutiquement acceptable de ces derniers) tels que définis dans le descriptif, des compositions pharmaceutiques contenant ces derniers, et leur utilisation en tant qu'inhibiteur du facteur Xa. L'invention concerne également un procédé de préparation ainsi que des intermédiaires utilisés dans la préparation.
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