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1. WO2000039097 - IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF

Publication Number WO/2000/039097
Publication Date 06.07.2000
International Application No. PCT/JP1999/007160
International Filing Date 20.12.1999
Chapter 2 Demand Filed 08.06.2000
IPC
C07D 233/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
C07D 233/90 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
66with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 233/94 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
66with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
91Nitro radicals
92attached in position 4 or 5
94with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
C07D 405/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
C07D 409/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
C07D 409/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 233/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
64with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
C07D 233/90
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
66with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 233/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
66with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
91Nitro radicals
92attached in position 4 or 5
94with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
C07D 405/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
C07D 409/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
C07D 409/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • FUJISAWA PHARMACEUTICAL CO., LTD. [JP/JP]; 4-7, Doshomachi 3-chome, Chuo-ku Osaka-shi Osaka 541-8514, JP (AllExceptUS)
  • KAYAKIRI, Hiroshi [JP/JP]; JP (UsOnly)
  • ABE, Yoshito [JP/JP]; JP (UsOnly)
  • HAMASHIMA, Hitoshi [JP/JP]; JP (UsOnly)
  • SAWADA, Hitoshi [JP/JP]; JP (UsOnly)
  • ISHIBASHI, Naoki [JP/JP]; JP (UsOnly)
  • SETOI, Hiroyuki [JP/JP]; JP (UsOnly)
  • OKU, Teruo [JP/JP]; JP (UsOnly)
  • YAMASAKI, Noritsugu [JP/JP]; JP (UsOnly)
  • IMOTO, Takafumi [JP/JP]; JP (UsOnly)
  • HIRAMURA, Takahiro [JP/JP]; JP (UsOnly)
Inventors
  • KAYAKIRI, Hiroshi; JP
  • ABE, Yoshito; JP
  • HAMASHIMA, Hitoshi; JP
  • SAWADA, Hitoshi; JP
  • ISHIBASHI, Naoki; JP
  • SETOI, Hiroyuki; JP
  • OKU, Teruo; JP
  • YAMASAKI, Noritsugu; JP
  • IMOTO, Takafumi; JP
  • HIRAMURA, Takahiro; JP
Agents
  • TAKASHIMA, Hajime; Yuki Bldg. 3-9, Hiranomachi 3-chome, Chuo-ku Osaka-shi Osaka 541-0046, JP
Priority Data
10/36736224.12.1998JP
11/22883812.08.1999JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF
(FR) COMPOSES D'IMIDAZOLE ET UTILISATION MEDICINALE DE CES COMPOSES
Abstract
(EN)
Imidazole compounds represented by general formula (I) and salts thereof and medicinal compositions containing the same. These compounds are useful in treating diseases which can be treated based on the hypoglycemic effect thereof, and diseases which can be treated based on the cGMP-PDE inhibitory effect, smooth muscular relaxant effect, bronchodilating effect, vasodilating effect, smooth muscle cell regulatory effect and allergy-inhibitory effects thereof, wherein each symbol is as defined in the description.
(FR)
La présente invention concerne des composés d'imidazole représentés par la formule générale (I), certains de leurs sels et des compositions médicinales à base de ces composés et de leurs sels. Ces composés conviennent au traitement d'une part d'affections contre lesquelles on peut intervenir, grâce à l'effet hypoglycémiant de ces composés, et d'autre part d'affections contre lesquelles on peut intervenir grâce à l'effet inhibiteur des cGMP-PDE, à l'effet myorelaxant des muscles lisses, à l'effet vasodilatateur, à l'effet cellulaire régulateur des muscles lisses, et à l'effet inhibiteur des allergies de ces composés. Les différents symboles de la formule sont tels que décrits dans la description.
Also published as
CZPV2001-2338
ININ/PCT/2001/1039/CHE
TR2001/01865
ZA200106040
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