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1. WO2000038836 - TISSUE COLLECTION DEVICES CONTAINING BIOSENSORS

Publication Number WO/2000/038836
Publication Date 06.07.2000
International Application No. PCT/US1999/031051
International Filing Date 27.12.1999
Chapter 2 Demand Filed 24.07.2000
IPC
C12Q 1/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
B82Y 15/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
15Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
B82Y 30/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
30Nanotechnology for materials or surface science, e.g. nanocomposites
C12Q 1/001
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
001Enzyme electrodes
G01N 2610/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2610Assays involving self-assembled monolayers [SAMs]
G01N 33/5438
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54366Apparatus specially adapted for solid-phase testing
54373involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
5438Electrodes
Applicants
  • CLINICAL MICRO SENSORS, INC. [US/US]; 101 Waverly Drive Pasadena, CA 91105, US
Inventors
  • KAYYEM, Jon, Faiz; US
Agents
  • SILVA, Robin, M. ; Flehr Hohbach Test Albritton & Herbert LLP Suite 3400 4 Embarcadero Center San Francisco, CA 94111-4187, US
Priority Data
60/114,17830.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TISSUE COLLECTION DEVICES CONTAINING BIOSENSORS
(FR) DISPOSITIFS DE PRELEVEMENT DE TISSU CONTENANT DES BIOCAPTEURS
Abstract
(EN)
The present invention provides tissue collection devices, particularly blood collection devices, comprising an electrode. The electrodes may further comprise self-assembled monolayers and capture binding ligands, particularly nucleic acid capture probes. The monolayers may comprise insulators and/or electroconduit-forming species (EFS). The devices may further comprise at least one reagent, including anticoagulants, probe nucleic acids, and lysis reagents. In a further aspect, the invention provides methods of detecting a target analyte in a sample comprising applying an initiation signal to a tissue collection device comprising an electrode. The electrode may comprise a self-assembled monolayer and an assay complex comprising a capture binding ligand, the target analyte and an electron transfer moiety. The methods further comprise detecting electron transfer between the electrode and the electron transfer moiety. The methods may further comprise collecting the sample, for example using blood collection equipment.
(FR)
La présente invention concerne des dispositifs de prélèvement de tissu, en particulier des dispositifs de prélèvement de sang, qui comportent une électrode. Les électrodes peuvent en outre comporter des monocouches auto-assemblées et des ligands de capture par liaison, notamment des sondes de capture d'acides nucléiques. Les monocouches peuvent comporter des espèces chimiques isolantes et/ou électroconductrices. Les dispositifs peuvent en outre comporter au moins un réactif, y compris des anticoagulants, des acides nucléiques sondes, et des réactifs de lyse. Dans un autre aspect, l'invention concerne un procédé de détection d'un analyte voulu dans un échantillon, qui comporte les étapes consistant à appliquer un signal d'initiation à un dispositif de prélèvement de tissu comportant une électrode. L'électrode peut comporter une monocouche auto-assemblée et un complexe de titrage contenant un ligand de capture par liaison, l'analyte voulu et une fraction de transfert d'électrons. Les procédés comportent en outre une détection de transfert d'électrons entre l'électrode et la fraction de transfert d'électrons. Les procédés peuvent en outre comporter une étape de prélèvement d'échantillon, par exemple à l'aide de l'équipement de prélèvement de sang.
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