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1. WO2000038785 - METHODS FOR TREATING CERTAIN DISEASES USING NAALADASE INHIBITORS

Publication Number WO/2000/038785
Publication Date 06.07.2000
International Application No. PCT/US1999/031039
International Filing Date 29.12.1999
Chapter 2 Demand Filed 28.06.2000
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
CPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/66
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
Applicants
  • GUILFORD PHARMACEUTICALS INC. [US/US]; 6611 Tributary Street Baltimore, MD 21224, US
Inventors
  • SLUSHER, Barbara, S.; US
  • LU, Xi-Chun, May; US
  • WOZNIAK, Krystyna; US
Agents
  • NATH, Gary, M.; Nath & Associates 6th Floor 1030 15th Street N.W. Washington, D.C. 20005-1503, US
Priority Data
09/224,29131.12.1998US
09/425,19722.10.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATING CERTAIN DISEASES USING NAALADASE INHIBITORS
(FR) METHODES DE TRAITEMENT DE CERTAINES MALADIES UTILISANT DES INHIBITEURS DE NAALADASE
Abstract
(EN)
A method for regulating the release of TGF-$g(b) from living cells $i(in vitro) or $i(in vivo), comprising bringing the cells into contact with an effective amount of a NAALADase inhibitor. Such methods are believed to be useful for affecting neuroregeneration, cell proliferation, cell differentiation, extracellular matrix formation, myelination, inflammation, immune function, liver function, pancreatic function, angiogenesis, or wound healing; and/or preventing or treating diabetes.
(FR)
L'invention concerne un procédé permettant de réguler la libération de TGF-$g(b) de cellules vivantes $i(in vitro) ou $i(in vivo), qui comporte l'étape consistant à mettre les cellules en contact avec une quantité efficace d'un inhibiteur de NAALADase. Les procédés de l'invention permettent d'agir sur la neurorégénération, la prolifération cellulaire, la différenciation cellulaire, la formation de matrice extracellulaire, myélinisation, l'inflammation, la fonction immunitaire, la fonction hépatique, la fonction pancréatique, l'angiogenèse ou la cicatrisation des plaies; et/ou de prévenir ou traiter le diabète.
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