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1. WO2000038759 - BLOOD-RELATED DIALYSIS AND TREATMENT

Publication Number WO/2000/038759
Publication Date 06.07.2000
International Application No. PCT/AU1999/001172
International Filing Date 23.12.1999
Chapter 2 Demand Filed 01.06.2000
IPC
A61M 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators
16with membranes
A61M 1/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
B01D 57/02 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
57Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C123
02by electrophoresis
B01D 61/42 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
42Electrodialysis; Electro-osmosis
CPC
A61M 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators; ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
16with membranes
A61M 1/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
A61M 1/3403
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3403Regulation parameters
A61M 1/3406
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3403Regulation parameters
3406Physical characteristics of the filtrate, e.g. urea
B01D 57/02
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
57Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
02by electrophoresis
B01D 61/425
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis, ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
42Electrodialysis; Electro-osmosis ; Electro-ultrafiltration
425Electro-ultrafiltration
Applicants
  • GRADIPORE LIMITED [AU/AU]; Riverside Corporate Park 35-105 Delhi Road North Ryde, NSW 2113, AU
Inventors
  • CHAN, Grace, Sze, Man; AU
  • FARAMUS, Ellie; AU
  • LEE, Jason, Ian, Kien, Huat; AU
  • NAIR, Chenicheri, Hariharan; AU
  • ROETH, Philip, John; AU
Agents
  • ALLENS PATENT & TRADE MARK SERVICES; G.P.O Box 50 Sydney, NSW 2001, AU
Priority Data
PP 790823.12.1998AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BLOOD-RELATED DIALYSIS AND TREATMENT
(FR) DIALYSE ET TRAITEMENT SANGUINS
Abstract
(EN)
A method of treating blood or plasma of a subject to remove metabolic contaminants, the method comprising: (a) placing blood or plasma from the subject in a first solvent stream, the first solvent stream being separated from a second solvent stream by an electrophoretic membrane; (b) applying an electric potential between the two solvent streams causing movement of metabolic contaminants from the blood or plasma through the membrane into the second solvent stream while cellular and biomolecular components of the blood or plasma are substantially retained in the first sample stream, or if entering the membrane, being substantially prevented from entering the second solvent stream; (c) optionally, periodically stopping and reversing the electric potential to cause movement of any cellular and biomolecular components of the blood or plasma having entered the membrane to move back into the first solvent stream, wherein substantially not causing any metabolic contaminants that have entered the second solvent stream to re-enter first solvent stream; (d) maintaining step (b), and optionally step (c) if used, until the desired amount of removal of the metabolic contaminants from the blood or plasma in the first solvent stream is achieved; and (e) returning the treated blood or plasma in the first solvent stream to the subject.
(FR)
La présente invention concerne une méthode de traitement du sang ou du plasma d'un sujet destinée à retirer les contaminants métaboliques, ce procédé consistant à: (a) placer le sang ou le plasma prélevé chez le sujet dans un premier flux de solvant, ce dernier étant séparé d'un second flux de solvant par une membrane électrophorétique; (b) appliquer un potentiel électrique entre les deux flux de solvants afin de permettre le déplacement des contaminants métaboliques du sang ou du plasma vers le second flux de solvant, en passant par ladite membrane, les composants cellulaires ou biomoléculaires du sang ou du plasma étant essentiellement retenus dans le premier flux de solvant, ou si ceux-ci traversent la membrane, ils ne réussiront pas à pénétrer le second flux de solvant; (c) éventuellement, arrêter ou inverser périodiquement le potentiel électrique pour déclencher le retour de tout composant cellulaire ou métabolique du sang ou du plasma ayant traversé la membrane vers le premier flux de solvant, tout en empêchant les contaminants métaboliques ayant pénétré le second flux de solvant de pénétrer de nouveau le premier flux de solvant; (d) maintenir l'opération (b), et éventuellement l'opération (c) si elle est utilisée, jusqu'à ce que la quantité de contaminants métaboliques désirée soit retirée du sang ou du plasma contenu dans le premier flux de solvant; et enfin (e) réinjecter au sujet le sang ou le plasma traité dans le premier flux de solvant.
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