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1. WO2000038732 - HYALURONATE LYASE USED FOR PROMOTING PENETRATION IN TOPICAL AGENTS

Publication Number WO/2000/038732
Publication Date 06.07.2000
International Application No. PCT/EP1999/010337
International Filing Date 22.12.1999
Chapter 2 Demand Filed 30.06.2000
IPC
A61K 8/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
06Emulsions
A61K 8/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
40containing nitrogen
A61K 8/41 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
40containing nitrogen
41Amines
A61K 8/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
40containing nitrogen
42Amides
A61K 8/49 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61K 8/60 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
60Sugars; Derivatives thereof
CPC
A61K 2800/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
70Biological properties of the composition as a whole
A61K 31/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
A61K 31/37
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
37Coumarins, e.g. psoralen
A61K 31/65
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
65Tetracyclines
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61K 38/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
51Lyases (4)
Applicants
  • ESPARMA GMBH [DE/DE]; Lange Göhren 3 D-39171 Osterweddingen, DE (AllExceptUS)
  • WOHLRAB, Wolfgang [DE/DE]; DE (UsOnly)
  • NEUBERT, Reinhard [DE/DE]; DE (UsOnly)
  • HUSCHKA, Christoph [DE/DE]; DE (UsOnly)
  • MÜLLER, Peter-Jürgen [DE/DE]; DE (UsOnly)
  • OZEGOWSKI, Jörg-Herman [DE/DE]; DE (UsOnly)
  • KOEGST, Dieter [DE/DE]; DE (UsOnly)
  • FRIES, Gerhard [DE/DE]; DE (UsOnly)
Inventors
  • WOHLRAB, Wolfgang; DE
  • NEUBERT, Reinhard; DE
  • HUSCHKA, Christoph; DE
  • MÜLLER, Peter-Jürgen; DE
  • OZEGOWSKI, Jörg-Herman; DE
  • KOEGST, Dieter; DE
  • FRIES, Gerhard; DE
Agents
  • PFENNING MEINIG & PARTNER GbR; Mozartstrasse 17 D-80336 München, DE
Priority Data
198 60 545.523.12.1998DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) HYALURONATLYASE ALS PENETRATIONSFORDERER IN TOPISCHEN MITTELN
(EN) HYALURONATE LYASE USED FOR PROMOTING PENETRATION IN TOPICAL AGENTS
(FR) HYALURONATE LYASE UTILISEE DANS DES MEDICAMENTS TOPIQUES COMME AGENT FACILITANT LEUR PENETRATION
Abstract
(DE)
Die Erfindung betrifft Mittel zur Behandlung von Hauterkrankungen und/oder Funktionsstörungen der Haut auf der Basis unterschiedlicher Arzneistoffe und/oder Hilfsstoffe durch Penetrationspromotion aus topischen Formulierungen in die Haut. Erfindungsgemäß setzt sich das Mittel aus einer mikrobiell hergestellten Hyaluronatlyase und einem Arzneistoff, vorzugsweise ein hydrophiler Problemarzneistoff und/oder Hilfsstoffen in unterschiedlichen galenischen Formulierungen einschließlich kolloidaler Trägersysteme eingearbeitet, zusammen. Die Anwendungsgebiete der Erfindung in der Human- und der Veterinärmedizin betreffen die Therapie, Prophylaxe und/oder Metaphylaxe von Hauterkrankungen, Funktionsstörungen der Haut, die Vorgänge der Hautalterung sowie trockene Hautzustände.
(EN)
The invention relates to agents for treating skin diseases and/or functional disorders of the skin by promoting penetration from topical formulations into the skin, said agents being based on different medicaments and/or auxiliary substances. According to the invention, the agent consists of a microbially produced hyaluronate lyase and a medicament, preferably a hydrophilic problem medicament, and/or auxiliary substances, processed into different galenic preparations including colloidal carrier systems. The invention is suitable for use in the areas of human and veterinary medicine for the therapy, prophylaxis and/or metaphylaxis of skin diseases, functional disorders of the skin, skin ageing processes and dry skin conditions.
(FR)
L'invention concerne des agents pour le traitement de maladies de la peau et/ou de troubles fonctionnels de la peau, à base de différents médicaments et/ou d'excipients, lesdits agents facilitant la pénétration dans la peau à partir de formulations topiques. L'agent selon l'invention contient une hyaluronate lyase produite par voie microbienne et un médicament, de préférence un médicament hydrophile posant des problèmes et/ou des excipients incorporés dans différentes formulations galéniques, y compris dans des systèmes de véhicules colloïdaux. En médecine humaine et vétérinaire, les agents selon l'invention s'utilisent pour la thérapie, la prophylaxie et/ou la métaphylaxie de maladies de la peau, de troubles fonctionnels de la peau, du vieillissement et de la déshydratation de la peau.
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