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1. WO2000038723 - COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND BILE ACID SEQUESTERING AGENTS FOR CARDIOVASCULAR INDICATIONS

Publication Number WO/2000/038723
Publication Date 06.07.2000
International Application No. PCT/US1999/027944
International Filing Date 17.12.1999
Chapter 2 Demand Filed 21.07.2000
IPC
A61K 31/137 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/343 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/4196 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41961,2,4-Triazoles
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61K 31/785 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
785Polymers containing nitrogen
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
CPC
A61K 31/785
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
785Polymers containing nitrogen
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • G.D. SEARLE LLC [US/US]; Corporate Patent Department P.O. Box 5110 Chicago, IL 60680-5110, US (AllExceptUS)
  • SIKORSKI, James, A. [US/US]; US (UsOnly)
  • GLENN, Kevin, C. [US/US]; US (UsOnly)
Inventors
  • SIKORSKI, James, A.; US
  • GLENN, Kevin, C.; US
Agents
  • WARNER, James, M. ; G.D. Searle & Co. Corporate Patent Department P.O. Box 5110 Chicago, IL 60080, US
  • WEISERT, Annekäte; Kraus & Weisert Thomas-Wimmer-Ring 15 D-80539 Munich, DE
Priority Data
60/113,95523.12.1998US
60/142,68207.07.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND BILE ACID SEQUESTERING AGENTS FOR CARDIOVASCULAR INDICATIONS
(FR) COMBINAISONS D'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE L'ESTER DE CHOLESTERYLE ET D'AGENTS SEQUESTRANTS DE L'ACIDE BILIAIRE, UTILISEES DANS LE CADRE DE TOUBLES CARDIO-VASCULAIRES
Abstract
(EN)
The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia and atherosclerosis. Combinations disclosed include a cholesteryl ester transfer protein inhibitor combined with a bile acid sequestrant.
(FR)
La présente invention concerne des combinaisons de composés de thérapie cardio-vasculaire, utilisées pour la prévention ou le traitement de troubles cardio-vasculaires, telles que l'hypercholestérolémie et l'athérosclérose. Cette invention fait intervenir des combinaisons comprenant un inhibiteur de la protéine de transfert de l'ester de cholestéryle combiné avec un agent séquestrant de l'acide biliaire.
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