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1. WO2000038693 - INTERLEUKIN-6 PRODUCTION INHIBITORS

Publication Number WO/2000/038693
Publication Date 06.07.2000
International Application No. PCT/JP1999/003346
International Filing Date 23.06.1999
IPC
A61K 31/675 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
CPC
A61K 31/663
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
A61K 31/675
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
Applicants
  • TORAY INDUSTRIES, INC. [JP/JP]; 2-1, Nihonbashi Muromachi 2-chome Chuo-ku Tokyo 103-8666, JP (AT, BE, CA, CH, CN, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, LU, MC, NL, PT, SE)
  • KOIKE, Junzo [JP/JP]; JP (UsOnly)
  • FUNABA, Yuriko [JP/JP]; JP (UsOnly)
  • TANAHASHI, Masahiko [JP/JP]; JP (UsOnly)
  • OKAZAKI, Seiji [JP/JP]; JP (UsOnly)
  • ITO, Masatoshi [JP/JP]; JP (UsOnly)
Inventors
  • KOIKE, Junzo; JP
  • FUNABA, Yuriko; JP
  • TANAHASHI, Masahiko; JP
  • OKAZAKI, Seiji; JP
  • ITO, Masatoshi; JP
Priority Data
10/37015025.12.1998JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) INTERLEUKIN-6 PRODUCTION INHIBITORS
(FR) INHIBITEURS DE LA PRODUCTION D'INTERLEUKINE-6
Abstract
(EN)
Drugs effective in the prevention and treatment of diseases due to abnormal production of interleukin-6, which are interleukin-6 production inhibitors containing as the active ingredient methanebis-phosphonic acid derivatives and exhibit an inhibitory effect against the production of interleukin-6. These drugs can be expected to be effective in the prevention and treatment of diseases in which interleukin-6 participates, for example, thrombocytosis, inflammatory diseases, immune response disorders, osteoporosis, rheumatoid arthritis, hypercalcemia, multiple myeloma, cachexia and nephritis.
(FR)
L'invention concerne des médicaments utilisés dans la cadre de la prévention et du traitement de maladies dues à une production anormale d'interleukine-6. Ces médicaments sont des inhibiteurs de la production d'interleukine-6, qui renferment, comme principe actif, des dérivés d'acide méthanebisphosphonique, et qui ont un effet inhibiteur vis-à-vis de la production d'interleukine-6. Ces médicaments peuvent être efficaces dans le cadre de la prévention et du traitement de maladies faisant intervenir l'interleukine-6, notamment la thrombocytose, les maladies inflammatoires, les dysfonctionnements de la réponse immunitaire, l'ostéoporose, la polyarthrite rhumatoïde, l'hypercalcémie, le myélome multiple, la cachexie et la néphrite.
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