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1. WO2000038681 - LIPOSOMIC NIFLUMIC ACID - NEW TRANSDERMAL ANTI-INFLAMMATORY MEDICINE

Publication Number WO/2000/038681
Publication Date 06.07.2000
International Application No. PCT/GR1999/000048
International Filing Date 22.12.1999
Chapter 2 Demand Filed 18.07.2000
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 31/465 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
465Nicotine; Derivatives thereof
CPC
A61K 31/465
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
465Nicotine; Derivatives thereof
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 9/1278
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1277Processes for preparing; Proliposomes
1278Post-loading, e.g. by ion or pH gradient
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
Applicants
  • P.N. GEROLYMATOS S.A. [GR/GR]; 13 Asklipiou GR-145 68 Kryoneri Attica, GR (AllExceptUS)
  • DEMETZOS, Konstantinos [GR/GR]; GR (UsOnly)
  • KAMMENOU, Helen [GR/GR]; GR (UsOnly)
  • RALLIS, Michalis [GR/GR]; GR (UsOnly)
  • PAPAIOANNOU, Georgios [GR/GR]; GR (UsOnly)
  • GEORGOPOULOS, Aristidis [GR/GR]; GR (UsOnly)
  • TSAMOURIS, Georgios [GR/GR]; GR (UsOnly)
  • HATZIANTONIOU, Sofia [GR/GR]; GR (UsOnly)
  • GIANNISIS, Georgios [GR/GR]; GR (UsOnly)
  • NOUNESIS, Georgios [GR/GR]; GR (UsOnly)
  • SAVVA-DIMOPOULOU, Christina [GR/GR]; GR (UsOnly)
Inventors
  • DEMETZOS, Konstantinos; GR
  • KAMMENOU, Helen; GR
  • RALLIS, Michalis; GR
  • PAPAIOANNOU, Georgios; GR
  • GEORGOPOULOS, Aristidis; GR
  • TSAMOURIS, Georgios; GR
  • HATZIANTONIOU, Sofia; GR
  • GIANNISIS, Georgios; GR
  • NOUNESIS, Georgios; GR
  • SAVVA-DIMOPOULOU, Christina; GR
Agents
  • PAPACONSTANTINOU, Helen, G.; 2 Coumbari Street GR-106 74 Athens, GR
Priority Data
98010046924.12.1998GR
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LIPOSOMIC NIFLUMIC ACID - NEW TRANSDERMAL ANTI-INFLAMMATORY MEDICINE
(FR) ACIDE NIFLUMIQUE LIPOSOMIQUE - UN NOUVEAU MEDICAMENT ANTI-INFLAMMATOIRE TRANSDERMIQUE
Abstract
(EN)
The present invention is referred to the encapsulation of the drug Niflumic acid in liposomes with the purpose to create a new transdermal non-steroidal anti-flammatory formulation. The Niflumic acid as well as its ester derivates, have been encapsulated into liposomes with different lipid formulations in order to achieve the increased effectiveness of the active compound. The liposome suspension, with or without the encapsulated drug has been formulated as a cream and a stability study of the final formulation has followed.
(FR)
La présente invention concerne l'encapsulation du médicament acide niflumique dans des liposomes dans le but de créer une nouvelle formulation anti-inflammatoire non stéroïdienne et transdermique. L'acide niflumique est ses dérivés esters ont été encapsulés dans les liposomes avec différentes formulations de lipides pour augmenter l'efficacité du composé actif. La suspension de liposomes, avec ou sans le produit encapsulé, a été formulée sous forme de crème. Par ailleurs, une étude de stabilité de la formulation finale a été effectuée.
Also published as
CZPV2001-2240
IS5964
NO20013015
NZ512126
SK200100796
SK7962001
US09857878
Latest bibliographic data on file with the International Bureau