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1. WO2000038680 - AZABICYCLOALKANES AS CCR5 MODULATORS

Publication Number WO/2000/038680
Publication Date 06.07.2000
International Application No. PCT/IB1999/002048
International Filing Date 23.12.1999
Chapter 2 Demand Filed 28.03.2000
IPC
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07D 207/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14Nitrogen atoms not forming part of a nitro radical
C07D 211/58 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56Nitrogen atoms
58attached in position 4
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 403/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
C07D 207/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14Nitrogen atoms not forming part of a nitro radical
C07D 211/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56Nitrogen atoms
58attached in position 4
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • PFIZER LIMITED [GB/GB]; Ramgsgate Road Sandwich Kent CT13 9NJ, GB (GB)
  • PFIZER, INC. [US/US]; 235 East 42nd Street New Nork, NY 10017, US (AE, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CR, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW)
  • ARMOUR, Duncan, Robert [GB/GB]; GB (UsOnly)
  • PRICE, David, Anthony [GB/GB]; GB (UsOnly)
  • STAMMEN, Blanda, Luzia, Christa [DE/GB]; GB (UsOnly)
  • WOOD, Anthony [GB/GB]; GB (UsOnly)
  • PERROS, Manoussos [GR/GB]; GB (UsOnly)
  • EDWARDS, Martin, Paul [GB/GB]; GB (UsOnly)
Inventors
  • ARMOUR, Duncan, Robert; GB
  • PRICE, David, Anthony; GB
  • STAMMEN, Blanda, Luzia, Christa; GB
  • WOOD, Anthony; GB
  • PERROS, Manoussos; GB
  • EDWARDS, Martin, Paul; GB
Agents
  • SPIEGEL, Allen, J.; c/o Simpson, Alison Urquhart-Dykes & Lord 30 Welbeck Street London W1M 7PG, GB
Priority Data
9828420.123.12.1998GB
9921375.310.09.1999GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AZABICYCLOALKANES AS CCR5 MODULATORS
(FR) AZABICYCLOALCANES MODULATEURS DE CCR5
Abstract
(EN)
Compounds of the Formula (I) [Region $g(a)] - [Region $g(b)] - [Region $g(g)] - [Region $g(d)] which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formlations and methods of treatment using these compounds.
(FR)
L'invention concerne des composés représentés par la formule (I) [Région $g(a)]- [Région $g(b)] [Région $g(g)] [Région $g(d)] qui sont utiles en tant que modulateurs de l'activité des chimiokines. L'invention concerne en outre des formulations pharmaceutiques et des traitements comprenant ces composés.
Also published as
CRCR2001-006392
CZPV2001-2298
GE5958/1
HRP20010468A
HRP20120132A
IS5944
NO20013183
NZ511794
RSP-388/01
SK200100875
TR2001/01793
UZ20010522
YUP-388/01
Latest bibliographic data on file with the International Bureau