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1. WO2000038674 - COMPOUNDS WHICH AFFECT mRNA STABILITY AND USES THEREFOR

Publication Number WO/2000/038674
Publication Date 06.07.2000
International Application No. PCT/CA1999/001234
International Filing Date 23.12.1999
Chapter 2 Demand Filed 11.07.2000
IPC
A61K 31/365 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
CPC
A61K 31/365
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
Applicants
  • NOVATION PHARMACEUTICALS INC. [CA/CA]; 1323 Regan Avenue Coquitlam, British Columbia V3J 3B6, CA (AllExceptUS)
  • KASTELIC, Tania [CA/CA]; CA (UsOnly)
  • CHENEVAL, Dominique [CH/CA]; CA (UsOnly)
  • RUETZ, Stephan [CH/CH]; CH (UsOnly)
Inventors
  • KASTELIC, Tania; CA
  • CHENEVAL, Dominique; CA
  • RUETZ, Stephan; CH
Agents
  • ROBINSON, J., christopher ; Smart & Biggar Box 11560, Vancouver Centre, Suite 2200 650 West Georgia Street Vancouver, British Columbia V6B 4N8, CA
Priority Data
9828707.124.12.1998GB
9828710.524.12.1998GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS WHICH AFFECT mRNA STABILITY AND USES THEREFOR
(FR) COMPOSES MODIFIANT LA STABILITE DE L'ARNm ET UTILISATIONS DE CES COMPOSES
Abstract
(EN)
Compounds which induce degradation of mRNA which contains one or more mRNA instability sequences are provided for use as pharmaceuticals, e.g. for use in the prophylaxis or treatment of diseases and medical conditions in general having an etiology associated with the increased or prolonged stability of mRNAs which contain one or more mRNA instability sequences, and which on prolonged or inappropriate expression typically give rise to undesirable effects, e.g. cancer cell growth or an unwanted inflammatory response.
(FR)
Cette invention se rapporte à des composés induisant une dégradation de l'ARNm qui contient une ou plusieurs séquences d'instabilité d'ARNm, ces composés pouvant servir d'agents pharmaceutiques, utiles notamment dans la prophylaxie ou le traitement des affections et des états pathologiques ayant de façon générale une étiologie associée à la stabilité accrue ou prolongée des ARNm qui contiennent une ou plusieurs séquences d'instabilité d'ARNm et qui, lors d'une expression prolongée ou inappropriée, engendrent généralement des effets indésirables, tels qu'une croissance des cellules cancéreuses ou une réponse inflammatoire non souhaitée.
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