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1. WO2000038669 - USE OF NALOXONE FOR PREVENTING AND TREATING THE DEGENERATION OF NEURONS

Publication Number WO/2000/038669
Publication Date 06.07.2000
International Application No. PCT/US1999/031070
International Filing Date 29.12.1999
Chapter 2 Demand Filed 26.07.2000
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
CPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
Applicants
  • OKLAHOMA MEDICAL RESEARCH FOUNDATION [US/US]; 825 NE 13th Street Oklahoma City, OK 73104, US (AllExceptUS)
  • BING, Guoying [CN/US]; US (UsOnly)
Inventors
  • BING, Guoying; US
Agents
  • HANSEN, Eugenia, S. ; Sidley & Austin Suite 3400 717 N. Harwood Dallas, TX 75201, US
Priority Data
60/114,21429.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF NALOXONE FOR PREVENTING AND TREATING THE DEGENERATION OF NEURONS
(FR) METHODE DE PREVENTION ET DE TRAITEMENT DE LA DEGENERATION DES NEURONES
Abstract
(EN)
The present invention discloses a technique for inducing Parkinson-like symptoms in animals by injection of LPS into the substantive nigra. Moreover, we disclose a method for preventing and treating the degeneration of neurons in a region of the brain, in particular the degeneration of dopaminergic neurons in the substantia nigra, which is associated with Parkinson's disease.
(FR)
La présente invention concerne une technique de provocation de symptômes de type Parkinson chez des animaux par injection de lipopolysaccharides dans le locus niger. L'invention concerne en outre une méthode de prévention et de traitement de la dégénération de neurones dans une région du cerveau, notamment la dégénération de neurones dopaminergiques dans le locus niger, associée à la maladie de Parkinson.
Also published as
Latest bibliographic data on file with the International Bureau