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1. WO2000038662 - THE MANIPULATION OF THE ACTIVITY OF A NITRIC OXIDE RADICAL PRODUCTION PATHWAY FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE PRESENCE OF OXYGEN FREE RADICALS

Publication Number WO/2000/038662
Publication Date 06.07.2000
International Application No. PCT/NL1999/000799
International Filing Date 23.12.1999
Chapter 2 Demand Filed 21.07.2000
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
A61K 31/375 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
375Ascorbic acid, i.e. vitamin C; Salts thereof
A61K 31/409 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
409having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
A61K 31/52 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
A61K 31/522 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
522having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
CPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
A61K 31/375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
375Ascorbic acid, i.e. vitamin C; Salts thereof
A61K 31/409
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
409having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
A61K 31/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
A61K 31/522
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
522having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
Applicants
  • STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER [NL/NL]; Lange Kleiweg 151 NL-2288 GJ Rijswijk, NL (AllExceptUS)
  • VAN DER MEIDE, Peter, Hendrikus [NL/NL]; NL (UsOnly)
Inventors
  • VAN DER MEIDE, Peter, Hendrikus; NL
Agents
  • OTTEVANGER, S., U.; Vereenigde Nieuwe Parklaan 97 NL-2587 BN The Hague, NL
Priority Data
98204437.223.12.1998EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THE MANIPULATION OF THE ACTIVITY OF A NITRIC OXIDE RADICAL PRODUCTION PATHWAY FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE PRESENCE OF OXYGEN FREE RADICALS
(FR) MANIPULATION DE L'ACTIVITE D'UN TRAJET DE PRODUCTION D'UN RADICAL DE MONOXYDE D'AZOTE POUR LE TRAITEMENT DE MALADIES ASSOCIEES A LA PRESENCE DE RADICAUX LIBRES D'OXYGENE
Abstract
(EN)
The invention discloses a novel pathway for the production of nitric oxide radicals. The invention teaches methods and compounds selected from the groups of porphyrin and purine derivatives such as 5,10,15,20-tetrakis (2,4,6-trimethyl-3,5-disulfonatophenyl) -prophyrinatoironIII (FeTMPS) and uric acid, respectively, and compounds such as deferoxamine (desferrioxamine), ascorbate and Trolex and a combination of two or more of said compounds, for affecting the activity of said pathway. At least one of the reaction products in said pathway is an oxygen free radical. By altering the activity of the pathway, diseases like lentivirus infection, human-immunodeficiency virus infection and allergic diseases may be treated.
(FR)
L'invention concerne un nouveau trajet de production de radicaux de monoxyde d'azote, ainsi que des procédés et composés qui permettent d'agir sur la l'activité dudit trajet, dans lequel au moins un produit de réaction est un radical libre d'oxygène. La modification de l'activité du trajet permet de traiter des maladies. Un procédé permettant de traiter un individu, dont l'état peut être affecté par des radicaux libres d'oxygène, consiste à lui administrer au moins un composé capable de modifier l'activité d'un trajet pour générer des radicaux de monoxyde d'azote.
Also published as
Latest bibliographic data on file with the International Bureau