Processing

Please wait...

Settings

Settings

1. WO2000038654 - SYNTHETIC AND THERAPEUTIC METHODS FOR THE ALPHA AND BETA DOMAINS OF METALLOTHIONEIN

Publication Number WO/2000/038654
Publication Date 06.07.2000
International Application No. PCT/US1999/030573
International Filing Date 21.12.1999
Chapter 2 Demand Filed 18.07.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07K 14/825 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
825Metallothioneins
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/001
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
001by chemical synthesis
C07K 14/825
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
825Metallothioneins
Applicants
  • VALLEE, Bert, L. [US/US]; US
Inventors
  • VALLEE, Bert, L.; US
Agents
  • ANTLER, Adriane, M. ; Pennie & Edmonds LLP 1155 Avenue of the Americas New York, NY 10036, US
Priority Data
60/113,45923.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHETIC AND THERAPEUTIC METHODS FOR THE ALPHA AND BETA DOMAINS OF METALLOTHIONEIN
(FR) PROCEDES SYNTHETIQUES ET THERAPEUTIQUES DES DOMAINES ALPHA ET BETA DE LA METALLOTHIONEINE
Abstract
(EN)
The present invention relates to the alpha and beta domains of metallothionein and analogs thereof, their synthesis, and therapeutic applications of them. Purified metal-free and metal containing alpha and beta domains of metallothionein are provided. A high yield method of synthesis and purification is also provided for the metal-free and metal containing alpha and beta domains of metallothionein. Finally, therapeutic methods are provided that use the alpha and beta domains of metallothionein to transport selected metals to specific tissues or to sequester metals from these tissues in order to treat conditions in those tissues that are ameliorated by the addition or sequestration of these metals.
(FR)
La présente invention concerne les domaines alpha et bêta de la métallothionéine et de ses analogues, leur synthèse, et leurs applications thérapeutiques, ainsi que des domaines alpha et bêta purifiés de cette protéine avec ou sans métal. L'invention concerne aussi un procédé de synthèse et de purification à haut rendement de ces domaines contenant ou ne contenant pas de métal, ainsi que des méthodes de soins qui utilisent les domaines alpha et bêta de la métallothionéine afin de transporter des métaux choisis vers des tissus spécifiques ou bien de séquestrer des métaux présents dans ces tissus de manière à traiter, dans ces tissus, des conditions associées à une amélioration par apport ou séquestration de ces métaux.
Also published as
Latest bibliographic data on file with the International Bureau