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1. WO2000038647 - SKIN PROTECTION AGENTS CONTAINING A FRAGMENT MIXTURE PRODUCED FROM HYALURONIC ACID BY HYDROLYSIS

Publication Number WO/2000/038647
Publication Date 06.07.2000
International Application No. PCT/EP1999/010336
International Filing Date 22.12.1999
Chapter 2 Demand Filed 30.06.2000
IPC
A61K 8/67 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
67Vitamins
A61K 8/73 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
72containing organic macromolecular compounds
73Polysaccharides
A61K 31/728 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726Glycosaminoglycans, i.e. mucopolysaccharides
728Hyaluronic acid
A61Q 19/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
CPC
A61K 31/728
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726Glycosaminoglycans, i.e. mucopolysaccharides
728Hyaluronic acid
A61K 8/676
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
67Vitamins
676Ascorbic acid, i.e. vitamin C
A61K 8/678
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
67Vitamins
678Tocopherol, i.e. vitamin E
A61K 8/735
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
72containing organic macromolecular compounds
73Polysaccharides
735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
16Emollients or protectives, e.g. against radiation
Applicants
  • ESPARMA GMBH [DE/DE]; Lange Göhren 3 D-39171 Osterweddingen, DE (AllExceptUS)
  • WOHLRAB, Wolfgang [DE/DE]; DE (UsOnly)
  • NEUBERT, Reinhard [DE/DE]; DE (UsOnly)
  • HUSCHKA, Christoph [DE/DE]; DE (UsOnly)
  • MÜLLER, Peter-Jürgen [DE/DE]; DE (UsOnly)
  • OZEGOWSKI, Jörg-Herman [DE/DE]; DE (UsOnly)
  • KOEGST, Dieter [DE/DE]; DE (UsOnly)
  • FRIES, Gerhard [DE/DE]; DE (UsOnly)
Inventors
  • WOHLRAB, Wolfgang; DE
  • NEUBERT, Reinhard; DE
  • HUSCHKA, Christoph; DE
  • MÜLLER, Peter-Jürgen; DE
  • OZEGOWSKI, Jörg-Herman; DE
  • KOEGST, Dieter; DE
  • FRIES, Gerhard; DE
Agents
  • PFENNING MEINIG & PARTNER GBR; Mozartstrasse 17 D-80336 München, DE
Priority Data
198 60 544.723.12.1998DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) MITTEL ZUM SCHUTZ DER HAUT, ENTHALTEND EIN AUS HYALURONSÄURE DURCH HYDROLYSE HERGESTELLTES FRAGMENTGEMISCH
(EN) SKIN PROTECTION AGENTS CONTAINING A FRAGMENT MIXTURE PRODUCED FROM HYALURONIC ACID BY HYDROLYSIS
(FR) AGENTS POUR PROTEGER LA PEAU, CONTENANT UN MELANGE DE FRAGMENTS PRODUIT PAR HYDROLYSE A PARTIR D'ACIDE HYALURONIQUE
Abstract
(DE)
Die Erfindung betrifft Mittel zur Behandlung, Prophylaxe und Metaphylaxe von Funktions- und Strukturstörungen der Haut infolge äußerer Einwirkungen. Das Mittel enthält eine mit einer mikrobiologischen Hyaluronatlyase partiell verdaute Hyaluronsäure. Das Hyaluronsäurefragmentgemisch wird in unterschiedliche galenische Formulierungen eingearbeitet, denen weitere hydrophile und/oder lipophile Wirkstoffe und/oder Hilfsstoffe zugesetzt werden können. Anwendungsgebiete der Erfindung in der Human- und Veterinärmedizin betreffen die Therapie und/oder die Prophylaxe von umweltbedingten, einschließlich UV-bedingten Hautschäden, trockenen Hautzuständen sowie die Hautalterung.
(EN)
The invention relates to an agent for the treatment, prophylaxis and metaphylaxis of functional and structural disorders of the skin caused by external factors. The agent contains a hyaluronic acid which has been partially digested with a microbiological hyaluronate lyase. The hyaluronic acid fragment mixture is processed into different galenic formulations to which other hydrophilic and/or lipophilic active ingredients and/or auxiliary substances can be added. The invention is suitable for use in human and veterinary medicine in the treatment and/or prophylaxis of skin damage caused by environmental factors, including UV; dry skin conditions and skin ageing.
(FR)
L'invention concerne des agents pour le traitement, la prophylaxie et la métaphylaxie de troubles fonctionnels ou structurels de la peau, consécutifs à des influences extérieures. Cet agent contient un acide hyaluronique partiellement digéré au moyen d'une hyaluronate lyase microbiologique. Le mélange de fragments d'acide hyaluronique est incorporé dans différentes formulations galéniques auxquelles peuvent être ajoutées d'autres principes actifs et/ou excipients hydrophiles et/ou lipophiles. En médecine humaine et vétérinaire, les agents selon l'invention s'utilisent pour la thérapie et/ou la prophylaxie de lésions de la peau dues à l'environnement, y compris dues à des UV, de la déshydratation et du vieillissement de la peau.
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