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1. WO2000038519 - 3-HETEROARYLIDENYL-2-INDOLINONE COMPOUNDS FOR MODULATING PROTEIN KINASE ACTIVITY AND FOR USE IN CANCER CHEMOTHERAPY

Publication Number WO/2000/038519
Publication Date 06.07.2000
International Application No. PCT/US1999/031232
International Filing Date 30.12.1999
Chapter 2 Demand Filed 31.07.2000
IPC
A61K 31/404 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61K 31/505 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
CPC
A61K 31/404
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61K 31/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Applicants
  • SUGEN, INC. [US/US]; 230 East Grand Avenue South San Francisco, CA 94080-4811, US
Inventors
  • LANGECKER, Peter, J.; US
  • SHAWVER, Laura, Kay; US
  • TANG, Peng, Cho; US
  • SUN, Li; US
Agents
  • BURROUS, Beth, A.; Foley & Lardner 3000 K. Street, N.W. Suite 500 Washington, DC 20007-5109, US
Priority Data
60/114,31331.12.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 3-HETEROARYLIDENYL-2-INDOLINONE COMPOUNDS FOR MODULATING PROTEIN KINASE ACTIVITY AND FOR USE IN CANCER CHEMOTHERAPY
(FR) COMPOSES 3-HETEROARYLIDENYL-2-INDOLINONE UTILISES POUR MODULATION DE L'ACTIVITE DE LA PROTEINE KINASE ET DANS LA CHIMIOTHERAPIE DU CANCER
Abstract
(EN)
The present invention relates to 3-heteroarylidenyl-2-indolinone compounds that modulate the enzymatic activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer. Furthermore, these compounds are expected to enhance the efficacy of other chemotherapeutic agents, in particular, fluorinated pyrimidines, in the treatment of cancer.
(FR)
La présente invention concerne des composés de 3-hétéroarylidényl-2-indoline qui modulent l'activité enzymatique des protéines kinase et devraient donc convenir pour la prévention et le traitement de maladies cellulaires en rapport avec la protéine kinase telle que le cancer. De plus, ces composés devraient améliorer l'efficacité d'autres agents chimiothérapeutiques, en particulier des pyrimidines fluorées, dans le traitement du cancer.
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