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1. WO2000037043 - FOAMING ANTACID SUSPENSION TABLETS

Publication Number WO/2000/037043
Publication Date 29.06.2000
International Application No. PCT/EP1999/009934
International Filing Date 14.12.1999
Chapter 2 Demand Filed 13.07.2000
IPC
A61K 9/46 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
46effervescent
A61K 33/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof
08Oxides; Hydroxides
A61K 33/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof
10Carbonates; Bicarbonates
A61K 33/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof
12Magnesium silicate
A61K 33/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
42Phosphorus; Compounds thereof
CPC
A61K 33/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof ; , e.g. clay
08Oxides; Hydroxides
A61K 33/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof ; , e.g. clay
10Carbonates; Bicarbonates
A61K 33/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof ; , e.g. clay
12Magnesium silicate
A61K 33/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
42Phosphorus; Compounds thereof
A61K 9/0007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
0007Effervescent
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Applicants
  • DR. REGENOLD GMBH [DE]/[DE] (AllExceptUS)
  • BAUER, Kurt, H. [DE]/[DE] (UsOnly)
Inventors
  • BAUER, Kurt, H.
Agents
  • ALBRECHT, Thomas
Priority Data
198 59 231.021.12.1998DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) SCHÄUMENDE ANTACIDA-SUSPENSIONSTABLETTEN
(EN) FOAMING ANTACID SUSPENSION TABLETS
(FR) COMPRIMES ANTIACIDES GENERANT DES SUSPENSIONS MOUSSANTES
Abstract
(DE)
Die Erfindung betrifft Antacida-Zubereitungen, umfassend die folgenden Bestandteile: (i) einen säurebindenden Wirkstoff (Antacidum) oder ein Gemisch solcher Wirkstoffe, (ii) eine CO2 freisetzende Brausemischung, (iii) ein polymeres Tensid als Schaumbildner oder ein Gemisch solcher Tenside, (iv) ein quellendes und gelbildendes Polymer oder ein Gemisch solcher Polymere und (v) gegebenenfalls übliche Hilfsstoffe sowie ein Verfahren zur Herstellung derartiger Antacida-Zubereitungen. Bei einer besonders bevorzugten Ausführungsform ist die Antacida-Zubereitung in Form einer Kautablette formuliert. Die erfindungsgemässen Antacida-Zubereitungen eignen sich zur symptomatischen Therapie von Ulcus duodeni, Ulcus ventriculi sowie Sodbrennen und säurebedingten Magenbeschwerden wie hyperacider Gastritis.
(EN)
The invention relates to antacid preparations comprising the following ingredients: (i) an acid binding active substance (Antacid) or a mixture of said active substances, (ii) a CO2 releasing effervescent mixture, (iii) a polymeric tenside as foaming agent or a mixture of said tensides, (iv) a swelling and gel-forming polymer or a mixture of said polymers and (v) optionally common adjuvants. The invention also relates to a method for the production of said antacid preparations. In a preferred embodiment, the antacid preparations are formulated in the form of a chewable tablet. The antacid preparations disclosed in the invention are suitable for symptomatic treatment of duodenal ulcer, gastric ulcer, heartburn and acid related gastric problems such as gastric hyperacidity.
(FR)
L'invention concerne des préparations antiacides, caractérisées en ce qu'elles renferment les composants ci-après: (i) une substance active à liaison aux acides (antiacide), ou un mélange de telles substances actives, (ii) un mélange effervescent dégageant du CO2, (iii) un tensioactif polymère en tant qu'agent moussant ou un mélange de tels tensioactifs, (iv) un polymère gonflant ou gélifiant, ou un mélange de tels polymères, et (v), éventuellement, des produits auxiliaires de type courant. L'invention concerne également un procédé de fabrication de telles préparations antiacides. Selon une forme d'exécution particulièrement préférée, la préparation antiacide est formulée sous la forme d'un comprimé à mâcher. Les préparations antiacides selon l'invention conviennent pour le traitement symptomatique de l'ulcère duodénal, de l'ulcère gastrique, ainsi que des aigreurs et des troubles gastriques dus aux acides, tels que l'hyperacidité gastrique.
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